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How to boost your biology? Every day strategies to improve therapies and combinations

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How to boost your biology? Every day strategies to improve therapies and combinations

Britta Siegmund 1

Affiliations

1 Charité - Universitätsmedizin Berlin, Berlin, Germany

Summary

AI Generated

The speaker outlined five strategies to optimize treatment outcomes in difficult-to-treat IBD patients, emphasizing early combination therapy, monitoring for loss of response, nutritional support, and distinguishing inflammatory from fibrotic disease.

The speaker stated that the Profile study showed 80% of patients achieved steroid and surgery-free remission at week 48 with immediate combination therapy (infliximab and thiopurine) versus step-up approach, with better first flare-free survival over one year
In patients with terminal ileitis and obstructive symptoms, the speaker emphasized distinguishing inflammation from fibrosis to avoid using expensive medical therapy when surgery is more appropriate
The speaker reported UK study data showing 40% of patients on combination therapy without a specific gene locus developed anti-drug antibodies versus 60% who did not, with higher rates on monotherapy
A study presented this year showed tasty and healthy diet (excluding processed food, gluten, red meat, and dairy except plain yogurt) had higher tolerability and clinical remission than exclusive enteral nutrition in mild-to-moderate Crohn's disease over 8 weeks
The speaker stated the Vigour trial demonstrated superiority of dual biologic therapy (golimumab plus guselkumab) versus monotherapy in the first 12 weeks, with prominent effect in the first 3-4 months, suggesting future potential for aggressive induction followed by monotherapy maintenance
The speaker described an immune escape mechanism where T cells express IL-23 receptor when anti-TNF blocks TNF signaling, suggesting IL-23 inhibitors as a good choice for anti-TNF non-responders without antibodies

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Abstract

Event

UEG Week Berlin 2025

Topics

IBD Mechanisms & Personalised Medicine Surgery

Session

How to optimise success in IBD treatment

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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Mesenchymal stem cell therapy: All just rubbish?

Christianne Johanna Buskens

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Mesenchymal stem cell therapy: All just rubbish?

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Mesenchymal stem cell therapy: All just rubbish?

Christianne Johanna Buskens 1

Affiliations

1 Academic Medical Center, Amsterdam, Netherlands

Summary

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Summary is not available for this content yet.

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Abstract

Event

UEG Week Berlin 2025

Topics

IBD Mechanisms & Personalised Medicine Surgery

Session

Focus on fistulising Crohn’s disease

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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MICROPLASTIC-INDUCED ALTERATIONS IN GUT MICROBIOME AND METABOLISM: INSIGHTS FROM AN EX VIVO BIOREACTOR MODEL

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MICROPLASTIC-INDUCED ALTERATIONS IN GUT MICROBIOME AND METABOLISM: INSIGHTS FROM AN EX VIVO BIOREACTOR MODEL

Christian Pacher-Deutsch 1,2, Kristina Žukauskaitė 1,2, Cigdem Akar 2, Maximilian Nepel 2, Lukas Kogler 1,3,4, Hansjörg Habisch 2, Serena Ducoli 5, Stefania Federici 5, Tobias Madl 2,6, Verena Pichler 1,3, Angela Horvath 1,2, Vanessa Stadlbauer 1,2,6

Affiliations

1 Center for Biomarker Research in Medicine (CBmed), Graz, Austria

2 Medical University of Graz, Graz, Austria

3 University of Vienna, Vienna, Austria

4 Medical University of Vienna, Vienna, Austria

5 University of Brescia, Brescia, Italy

6 BioTechMed-Graz, Graz, Austria

Summary

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Summary is not available for this content yet.

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Abstract

Introduction

Microplastic particles (MPs), defined as plastic fragments smaller than 5 mm, are pervasive pollutants that accumulate in ecosystems and the human food chain (1). Literature points at various health risks, including the induction of carcinogenesis (2). Emerging evidence from animal models (3) suggests that MPs may influence the gut microbiome, but the impact on the human gut microbiome remains poorly understood.

Aims & Methods

This study aimed to evaluate how various MP types influence gut microbial composition and metabolism using an ex vivo bioreactor model, with a focus on exploring potential carcinogenic effects arising from MP–microbiome interactions.
Stool samples from healthy donors were used to inoculate bioreactor cultures, which were maintained under anaerobic conditions for five days with daily nutrient feeding. These cultures were exposed to five common MP types—polystyrene (PS), polypropylene (PP), low-density polyethylene (LDPE), poly(methyl methacrylate) (PMMA), and polyethylene terephthalate (PET)—at concentrations mimicking both estimated human exposure (4) and higher doses to assess dose-dependence. Cell viability and total bacterial counts, as well as culture pH, were measured throughout the experiment. To further explore potential microbiome and metabolic alterations, 16S rRNA gene sequencing and targeted metabolomics were performed.

Results

MP exposure did not lead to significant changes in total or viable bacterial cell counts. However, MP-treated cultures exhibited a consistent and significant decrease in pH compared to controls, suggesting changes in microbial metabolic activity. Microbiome sequencing revealed plastic-type-dependent alterations in microbial composition, with certain bacterial taxa increasing or decreasing in abundance depending on the MP type. These shifts occurred across multiple genera within diverse families, including Lachnospiraceae, Oscillospiraceae, Enterobacteriaceae, and Ruminococcaceae, with the majority of changes occurring withing the phylum Bacillota. These compositional changes were accompanied by shifts in the metabolomic profiles, some of which correlated with the observed pH changes. Several plastic types induced changes in valeric acid levels, while individual MP types were associated with alterations in distinct metabolites such as uracil, lactic acid, and acetic acid.

Conclusion

This study demonstrates that MPs can affect gut microbial activity and metabolism without significantly altering overall bacterial abundance in the short term. The variation in microbiome response across plastic types highlights the complexity of MP-microbiome interactions. Changes in faecal pH are known to be associated with various gastrointestinal diseases (5). Interestingly, some of the MP-induced changes in microbial composition resembled patterns linked to diseases such as depression and colorectal cancer. In contrast, other changes showed patterns that differed from those typically associated with conditions like Parkinson’s disease and irritable bowel syndrome, highlighting the complexity of these associations and the dependency on the context. The bioreactor model provided a controlled environment for identifying direct MP-microbiome interactions; however, in humans, additional factors like diet, immune response, and individual microbiome variations play a role in determining long-term effects. Exposure duration may also play a critical role in shaping the extent and nature of microbiome alterations (6), underscoring the need for further research into the effects of chronic MP exposure and associated health risks.

References

(1) Mamun, A. A., Prasetya, T. A. E., Dewi, I. R., & Ahmad, M. (2023). Microplastics in human food chains: Food becoming a threat to health safety. The Science of the total environment, 858(Pt 1), 159834. https://doi.org/10.1016/j.scitotenv.2022.159834
(2) Kumar, R., Manna, C., Padha, S., Verma, A., Sharma, P., Dhar, A., Ghosh, A., & Bhattacharya, P. (2022). Micro(nano)plastics pollution and human health: How plastics can induce carcinogenesis to humans?. Chemosphere, 298, 134267. https://doi.org/10.1016/j.chemosphere.2022.134267
(3) Hirt, N., & Body-Malapel, M. (2020). Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature. Particle and fibre toxicology, 17(1), 57. https://doi.org/10.1186/s12989-020-00387-7
(4) Senathirajah, K., Attwood, S., Bhagwat, G., Carbery, M., Wilson, S., & Palanisami, T. (2021). Estimation of the mass of microplastics ingested - A pivotal first step towards human health risk assessment. Journal of hazardous materials, 404(Pt B), 124004. https://doi.org/10.1016/j.jhazmat.2020.124004
(5) Yamamura, R., Inoue, K. Y., Nishino, K., & Yamasaki, S. (2023). Intestinal and fecal pH in human health. Frontiers in Microbiomes, 2, 1192316.
(6) Yin, L., Yang, M., Teng, A., Ni, C., Wang, P., & Tang, S. (2025). Unraveling Microplastic Effects on Gut Microbiota across Various Animals Using Machine Learning. ACS nano, 19(1), 369–380. https://doi.org/10.1021/acsnano.4c07885

Event

UEG Week Berlin 2025

Topics

Gut Microbiota Colorectal

Submission format

Abstract

Session

The gut ecosystem: From pathogenesis to treatment

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

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IL-23

Laurent Peyrin-Biroulet 1

Affiliations

1 Inserm NGERE and University of Lorraine, Vandœuvre-lès-Nancy, France

Summary

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Abstract

Event

UEG Week Berlin 2025

Topics

IBD Mechanisms & Personalised Medicine

Session

What's new in advanced therapies for IBD in 2025?

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Which advanced therapy should you choose in patients with fistulising Crohn's disease?

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

Which advanced therapy should you choose in patients with fistulising Crohn's disease?

Krisztina Barbara Gecse 1

Affiliations

1 Amsterdam University Medical Center, Amsterdam, Netherlands

Summary

AI Generated

Summary is not available for this content yet.

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Abstract

Event

UEG Week Berlin 2025

Topics

IBD Mechanisms & Personalised Medicine Surgery

Session

Focus on fistulising Crohn’s disease

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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Mesenchymal stem cell therapy: All just rubbish?

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MICROPLASTIC-INDUCED ALTERATIONS IN GUT MICROBIOME AND METABOLISM: INSIGHTS FROM AN EX VIVO BIOREACTOR MODEL

Vanessa Stadlbauer

IL-23

Laurent Peyrin-Biroulet

Which advanced therapy should you choose in patients with fistulising Crohn's disease?

Krisztina Barbara Gecse

Identifying disease trajectories by AI

Florian Tran

Green endoscopy: Step by step to a paper free endoscopy unit

Konstantinos Triantafyllou

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

Identifying disease trajectories by AI

Florian Tran 1

Affiliations

1 University Medical Center Schleswig-holstein, Campus Kiel, Kiel, Germany

Summary

AI Generated

Summary is not available for this content yet.

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Abstract

Event

UEG Week Berlin 2025

Topics

Histopathology IBD Nurses

Session

The art of making clinical research precise: AI – friend or foe?

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Green endoscopy: Step by step to a paper free endoscopy unit

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

Green endoscopy: Step by step to a paper free endoscopy unit

Konstantinos Triantafyllou 1

Affiliations

1 Attikon University General Hospital, Athens, Greece

Summary

AI Generated

Summary is not available for this content yet.

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Abstract

Event

UEG Week Berlin 2025

Topics

Nurses

Session

Green endoscopy: What makes sense?

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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Mesenchymal stem cell therapy: All just rubbish?

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