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UEG Presentation

IMPACT OF COMBINED PROTON-PUMP INHIBITOR AND RIFAXIMIN THERAPY IN PATIENTS WITH FUNCTIONAL DYSPEPSIA: A RANDOMIZED CONTROLLED TRIAL

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IMPACT OF COMBINED PROTON-PUMP INHIBITOR AND RIFAXIMIN THERAPY IN PATIENTS WITH FUNCTIONAL DYSPEPSIA: A RANDOMIZED CONTROLLED TRIAL

Lingling Zhu 1, Huaizhu Guo 1, Jiaqi Gao 1, Siqi Lu 1, Zuojing Liu 1, Chen Chen 1, Kun Wang 1, Liping Duan 1

Affiliations

1 Peking University Third Hospital, Beijing, China

Summary

AI Generated

In functional dyspepsia patients, combining a proton pump inhibitor with rifaximin achieved superior symptom relief compared to PPI monotherapy at 4 weeks post-treatment (78.6% vs 48.9%, P=0.001).

The primary endpoint of symptom relief rate at 4 weeks post-treatment was significantly higher in the PPI plus rifaximin group versus PPI alone in both intention-to-treat analysis (77.1% vs 47.9%, P=0.001) and per-protocol analysis (78.6% vs 48.9%, P=0.001).
Combination therapy led to a significantly greater reduction in duodenal eosinophil infiltration (P=0.036) and decreased peak hydrogen sulfide levels (P<0.001), indicating reduced small intestinal bacterial load.
The PPI plus rifaximin intervention increased oral microbiota beta-diversity and the relative abundance of Enterococcus (P=0.004), while PPI monotherapy enriched the potentially pathogenic bacterium Catonella (P=0.006).
Treatment responders in the combination group showed specific enrichment of Eubacterium_yurii_group (P=0.037), which was associated with amelioration of duodenal eosinophilic inflammation and enhancement of pathways preventing bacterial epithelial invasion.
The oral abundance of Eubacterium_yurii_group may serve as a biomarker for treatment response in functional dyspepsia patients.
Combination therapy demonstrated a good safety profile with no serious adverse events reported in this open-label randomized controlled trial of 96 patients.

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This summary was generated by an AI large language model based on the content transcript. It is for informational purposes only and should not be considered a substitute for clinical judgment. Always rely on your professional expertise and the full clinical context when making clinical decisions.

Abstract

Introduction

Functional dyspepsia (FD) is associated with duodenal eosinophilia and gut microbiota dysbiosis. Proton pump inhibitors (PPIs), as a first-line therapy, can suppress duodenal eosinophilic inflammation to ameliorate symptoms, yet the symptom relief rate is low. Rifaximin (RIF), an antibiotic known to modulate the gut microbiota, may offer an alternative therapeutic avenue. It is hypothesized that combining RIF with PPIs could more effectively alleviate FD symptoms and duodenal inflammation by targeting the gut microbiota.

Aims & Methods

A single-center, open-label, randomized controlled clinical trial was conducted on subjects who met the inclusion and exclusion criteria (Trial registration: ChiCTR2300069313). Ninety-six patients were randomly assigned in a 1:1 ratio to either the PPI+RIF group or the PPI group. The follow-up period extended to 4 weeks post-treatment cessation. The primary endpoint was the symptom relief rate, while secondary endpoints included symptom response rate, duodenal eosinophil counts, and changes in the microbiota. The study hypothesis was that the clinical efficacy of PPI+RIF would be superior to that of PPI monotherapy.

Results

	PPI+RIF	PPI	Z value	P value	PPI+RIF	PPI	Z value	P value
Abbreviations: PPI+RIF: Proton Pump Inhibitor plus Rifaximin; PPI: Proton Pump Inhibitor; ITT: the intention-to-treat analysis;PP: the per-protocol analysis.
Symptom relief rate	ITT				PP
Week 2	54.2%（26/48）	54.2%（26/48）	0.000	0.500	53.7%（22/41）	53.3%（24/45）	0.030	0.488
Week 4	72.9%（35/48）	58.3%（28/48）	1.522	0.064	76.7%（33/43）	56.8%（25/44）	2.020	0.022
4 weeks post-treatment	77.1%（37/48）	47.9%（23/48）	3.095	0.001	78.6%（33/42）	48.9%（22/45）	3.036	0.001
Symptom response rate	ITT				PP
Week 2	70.8%（34/48）	72.9%（35/48）	-0.227	0.590	68.3%（28/41）	73.3%（33/45）	-0.514	0.696
Week 4	81.3%（39/48）	77.1%（37/48）	-0.503	0.307	83.7%（36/43）	75.0%（33/44）	1.012	0.156
4 weeks post-treatment	85.4%（41/48）	68.8%（33/48）	1.982	0.024	85.7%（36/42）	71.1%（32/45）	1.688	0.046

A total of 96 patients were enrolled in the randomized controlled study. There were no statistically significant differences in baseline demographic data and clinical characteristics between the two groups. According to the intention-to-treat (ITT) analysis, the PPI+RIF group showed significantly higher rates of symptom relief (P = 0.001) and symptom response (P = 0.024) at 4 weeks post-treatment. These findings were supported by the per-protocol (PP) analysis, which revealed a superior symptom relief rate for the combination group at both 4 weeks of treatment (P = 0.022) and 4 weeks post-treatment (P = 0.001), as well as a superior symptom response rate at 4 weeks post-treatment (P = 0.046). Combination therapy also led to a greater reduction in duodenal eosinophil infiltration (P = 0.036) and significantly decreased peak hydrogen sulfide (H₂S) levels (P < 0.001), indicating a reduction in small intestinal bacterial load. Oral microbiota analysis revealed that β-diversity of the oral flora increased following the PPI+RIF intervention, with an increased relative abundance of Enterococcus (P = 0.004). Conversely, the PPI intervention led to the enrichment of the potentially pathogenic bacterium Catonella (P = 0.006). Notably, treatment responders in the PPI+RIF group showed a specific enrichment of the Eubacterium_yurii_group (P = 0.037), an alteration associated with the amelioration of duodenal eosinophilic inflammation and the enhancement of pathways related to preventing bacterial invasion of the epithelium.

Conclusion

In patients with FD, combining a PPI with Rifaximin is superior to PPI monotherapy, improving both symptoms and duodenal eosinophil infiltration. This effect is linked to a reduction in H₂S-producing bacteria and a beneficial shift in the oral microbiota. The oral abundance of Eubacterium_yurii_group may serve as a biomarker for treatment response.