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IS MICROBIOTA CHARACTERIZATION A USEFUL TOOL IN CLINICAL PRACTICE? AN EXPLORATORY ANALYSIS OF PATIENTS FROM THE IBS.CONSTANT-CARE E-HEALTH MONITORING INITIATIVE

Marwah Al-sheikh 1, Dorit Vedel Ankersen 1, Mette Bennedsen 1, Christina Casén 2, Kristin Gravdal 2, Graceline Tina Kirubakaran 2, Johan Burisch 3,1, Pia Munkholm 1

Affiliations

1 North Zealand University Hospital, Greater Copenhagen, Denmark

2 Genetic Analysis AS, Oslo, Norway

3 Hvidovre University Hospital, Virum, Denmark

Summary

AI Generated

An exploratory study of IBS patients found that both low-FODMAP diet and probiotic treatment led to temporary microbiota changes in responders, with all one-year responders achieving normobiotic status.

In 25 IBS treatment responders, dysbiosis increased from 2 of 22 at baseline to 8 of 19 at four weeks, but all 15 responders providing one-year samples were normobiotic.
After four weeks, probiotic responders showed temporarily increased abundance of Bacilli, Lactobacillus spp., and Streptococcus salivarius ssp. thermophilus (p<0.05), while low-FODMAP diet responders showed decreased Anaerobutyricum hallii.
Baseline abundance of R. gnavus was greater in patients who responded to probiotics compared to those who responded to low-FODMAP diet.
The study used the standardized GA-map Dysbiosis Test Lx to characterize gut microbiota before treatment, at four weeks, and at one year in non-comorbid IBS patients from a previous trial.
The authors conclude that microbiota characterization is a promising monitoring tool for IBS treatments but more extensive studies are needed.

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This summary was generated by an AI large language model based on the content transcript. It is for informational purposes only and should not be considered a substitute for clinical judgment. Always rely on your professional expertise and the full clinical context when making clinical decisions.

Abstract

Introduction

Intestinal microbiota are prominent in the etiology of irritable bowel syndrome (IBS). In this exploratory study, we investigated short- and long-term changes in the microbiota of IBS patients after intervening with a low-FODMAP diet (LFD) or probiotics (an 8 strains lactobacilla) using a standardized microbiota characterization test intended for routine use.

Aims & Methods

We analyzed data and fecal samples collected in a previous trial from non-comorbid IBS patients before treatment, and then again after four weeks and one year of treatment. Response to treatment was defined by a reduction in the IBS-SSS score, and the gut microbiota were characterized using the standardized and GA-map® Dysbiosis Test Lx.

Results

Of the 25 responders to either treatment, two of the 22 with fecal samples available were dysbiotic at baseline, increasing to eight out of 19 after four weeks; after one year all responders providing a sample were normobiotic (n=15). After four weeks, the abundance of Bacilli, Lactobacillus spp. and Streptococcus salivarius ssp. thermophilus were temporarily increased in the probiotic responder group (p<0.05), while for LFD responders Anaerobutyricum hallii had decreased. There was a greater abundance of R. gnavus at baseline in those responding to probiotics than in those responding to LFD.

Conclusion

In addition to improving IBS symptoms, sustained LFD or repeat probiotics tended to temporarily alter the microbiota profile in responders. Microbiota characterization is a promising tool for monitoring IBS treatments; however, more extensive studies are needed.

Disclosure

Marwah Al-sheikh, Dorit Vedel Ankersen and Mette Bennedsen declare no conflict of interest
Christina Casén is an employee of Genetic Analysis AS and owns stocks and shares in Genetic Analysis AS.
Kristin Gravdal and Graceline Tina Kirubakaran are employees of Genetic Analysis AS.
Johan Burisch reports personal fees from AbbVie, grants and personal fees from Janssen-Cilag, personal fees from Celgene, grants and personal fees from MSD, personal fees from Pfizer, grants and personal fees from Takeda, grants and personal fees from Tillots Pharma, personal fees from Samsung Bioepis, grants and personal fees from Bristol Myers Squibb, grants from Novo Nordisk, personal fees from Pharmacosmos, personal fees from Ferring, personal fees from Galapagos, outside the submitted work.
Pia Munkholm has received consulting or lecture fees from AbbVie, Calpro A/S, Ferring Pharmaceuticals, Jansen-Cilag, Celgene, Takeda, Tillotts Pharma, Merck Sharp & Dohme, Pfizer, and research funds from Coloplast, Ferring Pharmaceuticals, Jansen-Cilag, Merck Sharp and Dohme, Pharmaforce, Svar A/S, Takeda, Tillotts Pharma, Novo Nordic.

Conference

UEG Week Copenhagen 2023

Topics

Colorectal

Submission format

Abstract

Session

PP 06 Other lower GI disorders (Posters)

Citation

United European Gastroenterology Journal 2023; 11 (Supplement 8)

Published

2023

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