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THE ADDED VALUE OF BLOOD GLUCOSE MONITORING IN HIGH-RISK INDIVIDUALS UNDERGOING PANCREATIC CANCER SURVEILLANCE

Aleksander Bogdanski 1, Derk Klatte 1, Anke Onnekink 1, Bas Boekestijn 1, Martin Wasser 1, Shirin Feshtali 1, Bert Bonsing 1, Sven Mieog 1, Jeanin van Hooft 1, Monique van leerdam 1,2

Affiliations

1 Leiden University Medical Center, Leiden, Netherlands

2 Netherlands Cancer Institute, Amsterdam, Netherlands

Summary

AI Generated

Longitudinal glucose monitoring showed no added diagnostic value for detecting pancreatic cancer in high-risk individuals with CDKN2A variants undergoing imaging-based surveillance.

Among 220 high-risk individuals in pancreatic surveillance, new-onset diabetes (NOD) did not significantly predict pancreatic cancer development (OR 1.21, 95% CI 0.39-3.78), and 82.1% of pancreatic cancer cases occurred without NOD.
NOD showed poor discrimination between individuals who did and did not develop pancreatic cancer (AUC 0.54, 95% CI 0.46-0.61).
Age was the only factor significantly associated with pancreatic cancer development (OR 1.05, 95% CI 1.01-1.1) in multivariable analysis.
The findings suggest that routine glucose measurements may not add value to imaging-based pancreatic cancer surveillance in CDKN2A variant carriers.

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Abstract

Introduction

New-onset diabetes (NOD) is associated with the development of pancreatic ductal adenocarcinoma (PDAC) and is suggested as potential biomarker to detect PDAC at an earlier stage. International guidelines recommend routine glucose measurements in pancreatic surveillance of high-risk individuals (HRIs), however, little is known about its added value in addition to imaging. Therefore, this study evaluates the added value of longitudinal glucose measurements as a diagnostic biomarker for PDAC in high-risk surveillance cohorts.

Aims & Methods

HRIs with a CDKN2A germline pathogenic variant participating in pancreatic cancer surveillance who had ≥ 1 fasting blood glucose (FBG) and/or HbA1c measurements were included in this study. Pancreatic surveillance consists of annual magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS), and blood sampling including blood glucose measurements. Individuals with diabetes mellitus at baseline, less than 3 years of follow-up and all follow-up after pancreatectomy were excluded from the study. Data was collected on demographics, FBG- and HbA1c measurements, MRI- and EUS examinations, and pathology reports. NOD was defined as two consecutive FBG values of ≥ 7 mmol/L or one HbA1c value of ≥ 48 mmol/mol. Univariate multivariable logistic regression was performed to assess the relationship between NOD and PDAC, with adjustment for sex, age and smoking history. To quantify the diagnostic performance of NOD as a marker for PDAC, receiver operating characteristic (ROC) curve and area under the curve (AUC) were computed.

Results

In total, 220 HRIs were included in the analysis. Median age was 61 (IQR 53-71) years, 62.7% of participants were female, and the mean BMI was 26.2 (4.12 SD). More than half (54.1%) of the studied cohort had a positive smoking history and the median amount of glucose measurements per person was 7 (IQR 5-12). During the study period, 26 (11.8%) HRIs developed NOD, of whom 5 (19.2%) later developed PDAC. The other 23 (82.1%) PDAC cases remained NOD-free. Multivariable analysis showed no statistically significant relationship between NOD and PDAC (OR 1.21; 95% CI, 0.39-3.78). A statistically significant association was exclusively observed between age and development of PDAC (OR 1.05; 95% CI, 1.01-1.1). Furthermore, NOD did not differentiate between HRIs with- and without PDAC (AUC 0.54; 95% CI, 0.46-0.61).

Conclusion

This study demonstrated no added value for longitudinal glucose monitoring in HRI participating in an imaging-based pancreatic cancer surveillance program.

Conference

UEG Week Copenhagen 2023

Topics

Pancreas

Submission format

Abstract

Session

Cystic and neuroendocrine neoplasms of the pancreas (Posters)

Citation

United European Gastroenterology Journal 2023; 11 (Supplement 8)

Published

2023

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Konrad Aden

PROSPECTIVE EVALUATION OF ACETIC ACID-ENHANCED MAGNIFYING ENDOSCOPY AS A SUBSTITUTE FOR CRYSTAL VIOLET STAINING IN PIT PATTERN CLASSIFICATION OF COLORECTAL EPITHELIAL NEOPLASMS

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Jun Nakahodo

UEG Presentation

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TRYPTOPHAN DEFICIENCY IS FREQUENT IN THE WESTERNIZED POPULATION AND INSTIGATES SEVERE COURSE OF INTERNAL-MEDICINE DISEASES

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TRYPTOPHAN DEFICIENCY IS FREQUENT IN THE WESTERNIZED POPULATION AND INSTIGATES SEVERE COURSE OF INTERNAL-MEDICINE DISEASES

Lina Welz 1, Jeanette Franzenburg 1, Sascha Thielke 1, Katrin Franzpötter 2, Sarah Meier 2, Corina Maetzler 1, Olaf Schneider 3, Jan Heyckendorf 1, Thomas Bahmer 1, Domagoj Schunk 1, Stefan Schreiber 4,1, Konrad Aden 1

Affiliations

1 University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

2 Christian-Albrechts-Universität zu Kiel, Kiel, Germany

3 Cerascreen, Leipzig, Germany

4 University Hospital Schleswig-Holstein, Kiel, Germany

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Abstract

Introduction

Micronutrient deficiency is an underestimated problem in the westernized population with unclear effects on the manifestation of acute or chronic disease. Westernized lifestyle instigates disrupted gut-microbial crosstalk and chronic low-grade inflammation¹. Tryptophan (Trp) is an essential amino acid used for de novo synthesis of cellular nicotinamide adenine dinucleotide (NAD). We have previously shown increased Trp degradation in several chronic inflammatory disorders, including IBD^2,3. Whether Trp deficiency is a widespread phenomenon in the western population is unknown. Here, we tested the hypothesis that Trp deficiency is frequent in the western population and associates with increased overall disease severity in internal-medicine and especially gastrointestinal (GI) diseases.

Aims & Methods

To screen the micronutrient status of the healthy population, we assessed quantitative amino acid levels in n=15.188 healthy controls (HC) with a commercially available home-care dry blood spot test for targeted metabolomics (cohort 1). Self-reported symptoms were assessed with a digital questionnaire. To validate Trp deficiency (defined as the lowest Trp quartile) in acute internal-medicine diseases (cohort 2), we measured serum Trp by HPLC in HC (n=291) and patients presenting in the emergency ward of the University Hospital Schleswig-Holstein, Kiel (n=4349, categorized by ICD10; thereof GI diseases n=516 (K00-K93: diseases of the digestive system); 10/2023-09/2024). Next to laboratory and clinical assessment at presentation, disease courses were followed up digitally for at least 6 months. Statistical analyses were performed with linear mixed models (LMM) and logistic regression correcting for age and sex at birth; predictive performance was evaluated via area under the receiver-operating-characteristic (AUROC; R version 4.4.1).

Results

In cohort 1, 39.3% of HC presented with Trp deficiency. Trp deficiency significantly inversely correlated with the amount of self-reported symptoms, such as e.g. GI symptoms. Validating these findings in internal-medicine and a subgroup of GI diseases in cohort 2, we found significantly reduced serum Trp compared to HC (mean Trp 56.58±10.84µM vs. 45.06±16.65 (all disease groups), 45.21±20.69 (GI diseases)), especially when the serum inflammation marker C-reactive protein was not elevated (<5 mg/l). Here, Trp deficiency was observed in 1.4% of HC, while it was strongly increased in all disease groups (26.6%) and GI diseases (30.2%). Using LMM, we found that patients that were hospitalized, admitted to the ICU or died within the follow-up period had a significantly lower Trp compared to patients with favourable outcomes (outpatient/no ICU/alive). Patients with Trp at the lowest compared to the highest quartile underwent longer hospitalisation and ICU treatment (all diseases: 3.17/0.37 days (d) longer; GI diseases: 3.91/0.48d longer) as well as a higher number of in-hospital procedures (all diseases: 1.47 more; GI diseases: 3.3 more). The predictive value of Trp for complicated outcomes (hospitalisation, hospitalisation >7d, ICU treatment, death) as assessed by AUROC was low-moderate (all diseases: AUC 0.69, 0.67, 0.61, 0.72; GI diseases: AUC 0.61, 0.6, 0.54 and 0.62, respectively).

Conclusion

We report that Trp deficiency is frequent in the westernized population and associates with more severe disease courses. Our data suggests Trp degradation along the de novo NAD synthesis pathway as an overarching metabolic hallmark of chronic low-grade inflammation and a risk factor for severe disease courses of internal-medicine and GI diseases.

References

1. Christ, A. & Latz, E. The Western lifestyle has lasting effects on metaflammation. Nature Reviews Immunology vol. 19 267–268 Preprint at https://doi.org/10.1038/s41577-019-0156-1 (2019).
2. Harris, D. M. M. et al. Tryptophan degradation as a systems phenomenon in inflammation – an analysis across 13 chronic inflammatory diseases. EBioMedicine 102, 105056 (2024).
3. Nikolaus, S. et al. Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases. Gastroenterology 153, (2017).

Event

UEG Week Berlin 2025

Topics

Gut Microbiota Small Intestine & Nutrition

Submission format

Abstract

Session

The gut ecosystem: From pathogenesis to treatment

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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Jun Nakahodo

UEG Presentation

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PROSPECTIVE EVALUATION OF ACETIC ACID-ENHANCED MAGNIFYING ENDOSCOPY AS A SUBSTITUTE FOR CRYSTAL VIOLET STAINING IN PIT PATTERN CLASSIFICATION OF COLORECTAL EPITHELIAL NEOPLASMS

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PROSPECTIVE EVALUATION OF ACETIC ACID-ENHANCED MAGNIFYING ENDOSCOPY AS A SUBSTITUTE FOR CRYSTAL VIOLET STAINING IN PIT PATTERN CLASSIFICATION OF COLORECTAL EPITHELIAL NEOPLASMS

Takeshi Shimizu 1, Taku Yamagata 1, Yoshihide Kanno 1, Megumi Tanaka 1, Tomohiro Shimada 1, Kai Korekawa 1, Hiroki Sato 1, Yutaka Eto 1, Yosei Sawai 1, Teruyuki Numata 1, Kei Ito 1

Affiliations

1 Sendai City Medical Center, Sendai, Japan

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Abstract

Introduction

In colorectal epithelial neoplasms, lesions classified as type 2B according to the Japan Narrow Band Imaging (NBI) Expert Team classification (JNET), which are characterized by irregular microsurface or microvascular patterns, are often difficult to diagnose accurately using NBI magnifying endoscopy (ME) alone. Therefore, supplementary pit pattern diagnosis using crystal violet (CV)-stained ME (CV-ME) is recommended. However, CV is potentially carcinogenic, and CV-ME is relatively complex and time-consuming. Acetic acid (AA)-enhanced NBI ME (ANBI-ME) has been proposed as a simpler and safer alternative. Based on our previous study identifying 4.5% AA as the optimal concentration[1], this study prospectively evaluated the diagnostic utility of 4.5% ANBI-ME as a substitute for CV-ME (UMIN registration number: 00045621).

Aims & Methods

From October 2021 to March 2024, colorectal lesions classified as JNET type 2B or 3 during colonoscopy were prospectively enrolled until 300 cases were included. Each lesion underwent ANBI-ME with 4.5% AA, followed by CV-ME. The area of suspected deepest invasion was selected, and one representative image from ANBI-ME and one from CV-ME were independently assessed by two expert endoscopists blinded to histopathology. Intermethod and interobserver agreement were evaluated using Cohen’s weighted kappa. Diagnostic accuracy for each modality was calculated using the individual and consensus diagnoses of the two experts (McNemar’s test). AA whitening duration (AD), representing a reversible mucosal reaction, was measured during ANBI-ME and analyzed by histological depth (low-grade dysplasia [LGD], high-grade dysplasia [HGD], superficial submucosal invasive carcinoma [SMs], and deep submucosal invasive carcinoma [SMd]) using Kaplan–Meier analysis and the log-rank test.

Results

After excluding four unresected lesions, 296 lesions were analyzed. Median lesion size was 18 mm. Locations included the cecum (30), ascending colon (47), transverse colon (69), descending colon (13), sigmoid colon (73), and rectum (64); 122 lesions were elevated and 174 flat. Histological diagnosis included 77 LGD, 145 HGD, 18 SMs, and 56 SMd. Good agreement was observed between modalities (κ = 0.65 and 0.62) and between observers (κ = 0.78 for ANBI-ME, κ = 0.66 for CV-ME). Consensus was reached in 216 ANBI-ME and 192 CV-ME cases. Diagnostic accuracy was significantly higher with ANBI-ME than CV-ME for both observers (81% vs. 76%, p = 0.028; 75% vs. 69%, p = 0.025). Among consensus cases, ANBI-ME also showed higher accuracy (66% vs. 57%, p < 0.01). Median AD (in seconds) was 52 for LGD, 80 for HGD, 132 for SMs, and 107 for SMd, with a significantly shorter duration observed in LGD (p < 0.001).

Conclusion

ANBI-ME demonstrated diagnostic performance equivalent to or superior to CV-ME for colorectal lesions classified as JNET type 2B or 3. In addition, AA whitening duration (AD) may complement the assessment of histological depth of invasion.

References

[1]. Shimizu T, Yamagata T, Kanno Y, et al. A single-center pilot study on the efficacy and safety of acetic acid-enhanced magnifying endoscopy with narrow-band imaging for diagnosis of colorectal epithelial neoplasms. Gastrointest Endosc. 2025;101(2):416-424.

Event

UEG Week Berlin 2025

Topics

Colorectal Digestive Oncology Endoscopy

Submission format

Abstract

Session

Lower GI: Before resection comes a good characterisation

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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Jun Nakahodo

UEG Presentation

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Specific key function of gut microbiota

Marius Vital 1

Affiliations

1 Deutsches Zentrum für Infektionsforschung, Braunschweig, Germany

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Abstract

Event

UEG Week Berlin 2025

Topics

Gut Microbiota Primary Care

Session

The art of making clinical research precise: Can we unlock the microbiome?

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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Konrad Aden

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Jun Nakahodo

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

How to improve quality in colonoscopy screening: Is AI the answer?

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How to improve quality in colonoscopy screening: Is AI the answer?

Yuichi Mori 1

Affiliations

1 University of Oslo / Showa University, Oslo, Norway

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Abstract

Event

UEG Week Vienna 2024

Topics

Colorectal Digestive Oncology Endoscopy

Session

Screening and surveillance of colorectal neoplasia

Citation

United European Gastroenterology Journal 2024; 12 (Supplement 8)

Published

2024

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Konrad Aden

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Kei Ito

Specific key function of gut microbiota

Marius Vital

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Yuichi Mori

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Mototsugu Kato

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Jun Nakahodo

UEG Presentation

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PROXIMAL COLONIC ADENOMA DETECTION WITH LINKED COLOR IMAGING VERSUS NARROW-BAND IMAGING－A RANDOMIZED CONTROLLED STUDY

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PROXIMAL COLONIC ADENOMA DETECTION WITH LINKED COLOR IMAGING VERSUS NARROW-BAND IMAGING－A RANDOMIZED CONTROLLED STUDY

Naohisa Yoshida 1, SHOKO ONO 2, Mio Matsumoto 3, Shuhei Hayasaka 4, Masaki Inoue 2, Ken Inoue 1, Momoko Tsuda 5, Reo Kobayashi 1, Ryo Takagi 2, Yusuke Nishimura 6, Sosuke Kato 3, Nobuaki Yagi 7, Naoya Sakamoto 8, Mototsugu Kato 5

Affiliations

1 Kyoto Prefectural University of Medicine, Kyoto, Japan

2 Hokkaido University Hospital, Sapporo, Japan

3 Sapporo Medical Center, NTT EC, Sapporo, Sapporo, Japan

4 Hokkaido University Graduate School of Medicine, Sapporo, Japan

5 National Hospital Organization Hakodate National Hospital, Hakodate, Japan

6 Kushiro Rosai Hospital, Kushiro, Japan

7 Asahi University Hospital, Gifu, Japan

8 Hokkaido University Graduate School of Medicine, Hokkaido, Japan

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Abstract

Introduction

Colorectal cancer is one of the most prevalent cancers with an estimated 1.8 million newly developed cases and 0.9 million cancer-related deaths in 2020.Resection of adenomatous polyps decreases the incidence and mortality of colorectal cancer. Narrow-band imaging (NBI) and linked color imaging (LCI) are the most predominantly conducted image-enhanced endoscopy using short-wavelength light but their usefulness in screening and surveillance colonoscopy remains controversial.

Aims & Methods

Our aim in this study was to investigate the superiority of LCI over NBI for ADR.
This is an open-label, two-arm, parallel, 1:1, multicenter, randomized, controlled, right-sided colonoscopy study and included patients who underwent colonoscopy at six endoscopy centers in Japan from November 2020 through November 2023. The patients were randomly assigned to undergo a proximal-sided colonoscopy (cecum and ascending colon) with LCI or 2G-NBI followed by WLI. The primary outcome included the ADR and secondary outcomes involved polyp detection rate (PDR), polyp miss rate, and adenoma miss rate. This study was registered on November 4, 2020, in the Japan Registry of Clinical Trials (jRCT1012200007).

Results

During the study period, 1,655 patients were randomly assigned to the LCI group (828 patients, primary LCI followed by secondary WLI) and the 2G-NBI group (827 patients, primary 2G-NBI followed by secondary WLI), and 776 patients in the LCI group and 752 patients in the 2G-NBI groups were finally analyzed. The ADRs were 26.7% and 23.4% and the PDRs were 32.6% and 28.9% in primary LCI and 2G-NBI, respectively, with no statistically significant differences in ADR and PDR between groups (P = 0.14 and P = 0.12). However, multivariate regression analysis revealed primary LCI observation as an independent predictor for reducing PDR in the secondary WLI (Odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.53−0.97, P = 0.029). Moreover, polyp analysis demonstrated that miss rates of adenomas and polyps were significantly lower in the LCI group than in the NBI group (OR: 0.54, 95% CI: 0.39−0.76 in adenoma; OR: 0.59, 95% CI: 0.44−0.78 in polyp).

Conclusion

LCI is not superior to 2G-NBI in ADR and PDR in a clinical right-sided colonoscopy setting. However, LCI significantly reduced miss rates of adenomas and polyps.

Disclosure

Naohisa Yoshida has received lecture and/or consulting fees from Fujifilm and Olympus; Shoko Ono has received lecture and/or consulting fees from Fujifilm and Olympus; Momoko Tsuda has received lecture and/or consulting fees from Fujifilm; Nobuaki Yagi have received lecture and/or consulting fees from Fujifilm and Olympus; Mototsugu Kato has received lecture and/or consulting fees from Fujifilm. The remaining authors disclose no conflicts.

Event

UEG Week Berlin 2025

Topics

Colorectal Endoscopy Surgery

Submission format

Abstract

Session

Improving decision-making in colorectal lesions

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

TRYPTOPHAN DEFICIENCY IS FREQUENT IN THE WESTERNIZED POPULATION AND INSTIGATES SEVERE COURSE OF INTERNAL-MEDICINE DISEASES

Konrad Aden

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Kei Ito

Specific key function of gut microbiota

Marius Vital

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Yuichi Mori

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Mototsugu Kato

ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION/BIOPSY FOR SMALL PANCREATIC CANCER ≤ 10 MM AND ADDITIONAL SALVAGE BY PANCREATIC JUICE CYTOLOGY: A MULTICENTRE STUDY

Jun Nakahodo

UEG Poster

Standard Poster

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ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION/BIOPSY FOR SMALL PANCREATIC CANCER ≤ 10 MM AND ADDITIONAL SALVAGE BY PANCREATIC JUICE CYTOLOGY: A MULTICENTRE STUDY

Ryota Sagami 1,2, Jun Nakahodo 3, Ryuki Minami 4, Kentaro Yamao 5, Akihiro Yoshida 6, Hidefumi Nishikiori 1, Mamoru Takenaka 6, Kazuhiro Mizukami 2, Kazunari Murakami 2

Affiliations

1 Oita San-ai Medical Center, Oita, Japan

2 Oita University, Faculty of Medicine, Yufu, Japan

3 Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo, Japan

4 Tenri Hospital, Nara, Japan

5 Nagoya University, Nagoya, Japan

6 Kindai University, Osaka-Sayama, Japan

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Abstract

Introduction

In the context of pancreatic ductal adenocarcinoma (PDAC) ≤ 10 mm in diameter, the diagnostic performance of endoscopic ultrasound-guided fine needle aspiration/biopsy (EUS-FNAB) is relatively low. Pancreatic juice cytology (PJC) has recently gained attention because of its high sensitivity for small PDAC. However, the appropriateness of EUS-FNAB/PJC for small PDAC is still controversial.

Aims & Methods

This study aimed to clarify the true diagnostic ability of EUS-FNAB and the salvage ability of PJC in PDAC ≤ 10 mm. A retrospective analysis was conducted on 271 patients with pancreatic tumors ≤ 10 mm confirmed by EUS, who were undergoing attempted EUS-FNAB. For accurate evaluation of the ability of EUS-FNAB to distinguish PDAC, pancreatic metastasis/malignant lymphoma were excluded. The technical success of EUS-FNAB was defined as the possibility of needle puncture and the ability to obtain adequate specimens for cytological/histological assessment. The diagnostic ability of EUS-FNAB was analyzed using technical success cases. A positive cytological diagnosis was defined as cells with highly suspected adenocarcinoma/definite adenocarcinoma based on the Bethesda system in both EUS-FNAB and PJC examinations. EUS-FNAB histological diagnosis was considered negative if only atypical cells existed. The diagnoses made with EUS-FNAB were determined based on cytology and/or histological findings. After eliminating technical failure or negative results by EUS-FNAB, patients with a strong likelihood of having PDAC from imaging characteristics underwent salvage PJC. The primary endpoint was clarifying the technical success rate/diagnostic ability of EUS-FNAB for PDAC ≤ 10 mm. In addition, the salvage ability of PJC for false-negative/technical failure EUS-FNAB cases was also examined.

Results

EUS-FNAB procedures were attempted for 271 patients with pancreatic tumors ≤ 10 mm. Overall, 80.8% of patients with pancreatic tumors (median lesion size of 8 mm [range, 3–10 mm]) achieved technical success. The reasons for technical failure were the inability to puncture due to anatomical inaccessibility (3.3%), unclear visibility for a puncture (5.2%), and inadequate specimen retrieval for cyto-histological analysis (10.7%).Actual diagnostic ability of EUS-FNAB in the diagnosis of PDAC ≤ 10 mm. In patients who achieved EUS-FNAB technical success, PDAC ≤ 10 mm was detected in 28.3% (62/219) of the patients with surgical resection/clinical follow-up. The sensitivity, specificity, and accuracy of comprehensive EUS-FNAB was 82.3%, 94.9%, and 91.3%, respectively. In the diagnostic ability comparison using AUC, comprehensive EUS-FNAB had naturally higher diagnostic ability than EUS-FNAB cytology alone/EUS-FNAB histology alone (P = 0.002, P < 0.001, respectively). In addition, EUS-FNAB cytology had higher diagnostic capability than EUS-FNAB histology alone (P = 0.034). Thirty-five patients were diagnosed with PDAC ≤ 10 mm from among the 212 patients who encountered technical failure/negative diagnosis by EUS-FNAB. Among these patients with PDAC ≤ 10 mm, 74.3% were additionally diagnosed by salvage PJC accurately (PJC positive and final diagnosis of PDAC ≤ 10 mm). The overall accuracy of PJC was 81.6% in this study. The other nine patients with PDAC ≤ 10 mm, who had not been accurately diagnosed by EUS-FNAB/PJC, were finally diagnosed by surgical resection/clinical follow-up based on their imaging findings.

Conclusion

The true technical success rate/sensitivity of EUS-FNAB for PDAC ≤ 10 mm was relatively low. EUS-FNAB followed by PJC may be ideal for diagnosing PDACs ≤ 10 mm in diameter.

Disclosure

Conflicts of interest: None declared.

Conference

UEG Week Copenhagen 2023

Topics

Pancreas

Submission format

Abstract

Session

PP 08 Pancreas (Posters)

Citation

United European Gastroenterology Journal 2023; 11 (Supplement 8)

Published

2023

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