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By far the most common risk factors for the development of acute pancreatitis are excessive alcohol consumption and gallstone disease. Several mutations have been identified that, in combination with nongenetic factors or alone, can lead to pancreatitis. Certain drugs are known to be associated with the development of pancreatitis and smoking might also increase the probability of it developing. 80–85% of patients diagnosed with the disease will have mild disease and make an uneventful recovery with little more than adequate fluid therapy and analgesia needed to support them. The remaining patients, however, will suffer from moderately severe to severe acute pancreatitis, with the development of pancreatic necrosis, severe sepsis or abdominal compartment syndrome. These patients are at immediate danger of multiorgan failure and death and require multidisciplinary intensive care, organ support and often pancreatic interventions conducted by experienced investigators. Since it is difficult to predict outcomes and complications develop during the disease course, treatment in specialized centres that have a high case load is recommended.4

Mistakes in the management of acute pancreatitis and how to avoid them

Mistakes in the management of acute pancreatitis and how to avoid them

Peter Simon, Markus M. Lerch, Julia Mayerle, Georg Beyer, Elisabeth Orgler-Gasche

Topics

Pancreas

Citation

Beyer G, et al. Mistakes in the management of acute pancreatitis and how to avoid them. UEG Education 2016: 16: 27–30.

Published

2024
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Alteration of common coagulation tests and thrombocytopenia represent an integral part of the clinical picture of patients with advanced chronic liver disease. As such, the International Normalised Ratio (INR) for prothrombin time is part of the Model for End-stage Liver Disease (MELD) score, which is commonly used to assess prognosis and the need for liver transplantation in patients with cirrhosis. Thrombocytopenia—being mainly related to hypersplenism and decreased synthesis of thrombopoietin by the liver—can also be used to identify the presence of portal hypertension and decreased liver function in patients with chronic liver disease.


Mistakes in coagulation in liver disease and how to avoid them

Mistakes in coagulation in liver disease and how to avoid them

Edoardo G. Giannini

Topics

Hepatobiliary

Citation

Giannini EG and Caldwell SH. Mistakes in coagulation in liver disease and how to avoid them. UEG Education 2021; 21: 29–34.

Published

2021
UEG Standards and Guidelines
Clinical Practice Guideline
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Summary

Both acute and chronic pancreatitis are frequent diseases of the pancreas, which, despite being of benign nature, are related to a significant risk of malnutrition and may require nutritional support. Acute necrotizing pancreatitis is encountered in 20% of patients with acute pancreatitis, is associated with increased morbidity and mortality, and may require artificial nutrition by enteral or parenteral route, as well as additional endoscopic, radiological or surgical interventions. Chronic pancreatitis represents a chronic inflammation of the pancreatic gland with development of fibrosis. Abdominal pain leading to decreased oral intake, as well as exocrine and endocrine failure are frequent complications of the disease. All of the above represent risk factors related to malnutrition. Therefore, patients with chronic pancreatitis should be considered at risk, screened and supplemented accordingly. Moreover, osteoporosis and increased facture risk should be acknowledged in patients with chronic pancreatitis, and preventive measures should be considered.

Keywords: Acute pancreatitis, Chronic pancreatitis, Pancreatic diseases, Nutrition, Nutritional support, Medical Nutrition

ESPEN guideline on clinical nutrition in acute and chronic pancreatitis

ESPEN guideline on clinical nutrition in acute and chronic pancreatitis

Marianna Arvanitakis

Publisher

The European Society for Clinical Nutrition and Metabolism logo
The European Society for Clinical Nutrition and Metabolism

Guideline

Clinical Practice Guideline

Topics

Pancreas Small Intestine & Nutrition

Citation

Clinical Nutrition, Volume 39, Issue 3, 612 - 631

Published

2020
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UEG Standards and Guidelines
Position Paper
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Abstract

Digestiva (Spanish Society of Digestive Endoscopy) and the Sociedad Espanola de Anatomía Patológica (Spanish Society of Pathology), aims to establish recommendations for the screeningof gastric cancer (GC) in low incidence populations, such as the Spanish. To establish the quality of the evidence and the levels of recommendation, we used the methodology based on theGRADE system (Grading of Recommendations Assessment, Development and Evaluation). We obtained a consensus among experts using a Delphi method. The document evaluates screening in the general population, individuals with relatives with GC and subjects with GC precursor lesions (GCPL). The goal of the interventions should be to reduce GC-related mortality. We recommend the use of the OLGIM classification and to determine the intestinal metaplasia(IM) subtype in the evaluation of GCPL. We do not recommend establishing endoscopic massscreening for GC or H. pylori. However, the document strongly recommends treating H. pylori if the infection is detected, and investigation and treatment in individuals with a family history of GC or with GCPL. Meanwhile, we recommend against the use of serological tests to detect GCPL. Endoscopic screening is suggested only in individuals that meet familial GC criteria. As for individuals with GCPL, endoscopic surveillance is only suggested in extensive IM associated with additional risk factors (incomplete IM and/or a family history of GC), after resection of dysplastic lesions or in patients with dysplasia without visible lesion after a high-quality gastroscopy with chromoendoscopy.

Keywords: Helicobacter pylori; Mass screening; Chronic gastritis; Intestinal metaplasia; Dysplasia; Familial gastric cancer

Gastric cancer screening in low incidence populations: Position statement of AEG, SEED and SEAP

Gastric cancer screening in low incidence populations: Position statement of AEG, SEED and SEAP

Joaquín Cubiella

Guideline

Position Paper

Topics

Digestive Oncology Endoscopy Histopathology Stomach & H. Pylori

Citation

Gastroenterol Hepatol . 2021 Jan;44(1):67-86.

Published

2021
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Abstract

Pancreatic exocrine insufficiency (PEI) is defined as a reduction in pancreatic exocrine secretion below the level that allows the normal digestion of nutrients. Pancreatic disease and surgery are the main causes of PEI. However, other conditions and upper gastrointestinal surgery can also affect the digestive function of the pancreas. PEI can cause symptoms of nutritional malabsorption and deficiencies, which affect the quality of life and increase morbidity and mortality. These guidelines were developed following the United European Gastroenterology framework for the development of high-quality clinical guidelines. After a systematic literature review, the evidence was evaluated according to the Oxford Center for Evidence-Based Medicine and the Grading of Recommendations Assessment, Development, and Evaluation methodology, as appropriate. Statements and comments were developed by the working groups and voted on using the Delphi method. The diagnosis of PEI should be based on a global assessment of symptoms, nutritional status, and a pancreatic secretion test. Pancreatic enzyme replacement therapy (PERT), together with dietary advice and support, are the cornerstones of PEI therapy. PERT is indicated in patients with PEI that is secondary to pancreatic disease, pancreatic surgery, or other metabolic or gastroenterological conditions. Specific recommendations concerning the management of PEI under various clinical conditions are provided based on evidence and expert opinions. This evidence-based guideline summarizes the prevalence, clinical impact, and general diagnostic and therapeutic approaches for PEI, as well as the specifics of PEI in different clinical conditions. Finally, the unmet needs for future research are discussed.

European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations

European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations

Juan Enrique Dominguez-Munoz

Publishers

European Society for Primary Care Gastroenterology logoEuropean Society of Digestive Oncology logoEuropean Society for Paediatric Gastroenterology, Hepatology and Nutrition logoThe European Society for Clinical Nutrition and Metabolism logoEuropean Digestive Surgery logoEuropean Pancreatic Club logo
European Society for Primary Care Gastroenterology, European Society of Digestive Oncology, European Society for Paediatric Gastroenterology, Hepatology and Nutrition, The European Society for Clinical Nutrition and Metabolism, European Digestive Surgery, European Pancreatic Club

Guideline

Clinical Practice Guideline

Topics

Pancreas

Citation

United European Gastroenterol J. 2024; 1–48. https://doi.org/10.1002/ueg2.12674

Published

2024
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Summary

The EASL Clinical Practice Guidelines (CPGs) on the management of hepatic encephalopathy (HE) present evidence-based answers to a set of relevant questions (where possible, formulated in PICO [patient/population, intervention, comparison and outcomes] format) on the definition, diagnosis, differential diagnosis and treatment of HE. The document does not cover the pathophysiology of HE and does not cover all available treatment options. The methods through which it was developed and any information relevant to its interpretation are also provided.

EASL Clinical Practice Guidelines on the management of hepatic encephalopathy

EASL Clinical Practice Guidelines on the management of hepatic encephalopathy

Publisher

European Association for the Study of the Liver logo
European Association for the Study of the Liver

Guideline

Clinical Practice Guideline

Topics

Hepatobiliary

Citation

Journal of Hepatology, Volume 77, Issue 3, 807 - 824

Published

2022
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Alcohol consumption is the most prevalent aetiology for liver cirrhosis in Europe and the third leading risk factor for overall mortality.1,2 In fact, alcoholic liver cirrhosis accounts for almost half a million deaths a year worldwide, corresponding to 50% of all cases of cirrhosis, according to the World Health Organization (WHO).3 Alcoholic liver disease (ALD) is multifaceted, with several cofactors influencing its progression. Patients abusing alcohol can simultaneously have viral hepatitis B or C, or a genetic disease, such as alpha-1 antitrypsin deficiency or haemochromatosis.

Mistakes in alcoholic liver disease and how to avoid them

Mistakes in alcoholic liver disease and how to avoid them

Helena Cortez-Pinto, Pedro Marques Da Costa

Topics

Hepatobiliary

Citation

Marques da Costa P and Cortez-Pinto H. Mistakes in alcoholic liver disease and how to avoid them. UEG Education 2017: 17; 10–14.

Published

2024

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