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HUMAN MICROBIOTA DIVERSITY IN TISSUE SAMPLES OF UPPER AND LOWER GI TRACT

Martin Vrško 1, Emeše Majorova 1, Natália Vaňová 1, Štefan Mucha 1, Jana Krokošová 2

Affiliations

1 University of Pavol Jozef Šafárik in Košice, Medical Faculty, Košice-Šaca, Slovakia

2 Agellab Slovakia, Zvolen, Slovakia

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Abstract

Introduction

The microbiota of human gastrointestinal tract is a complex and dynamic population of microorganisms and plays a major role in the maintenance of gut health and disease conditions. The microbial population, structure and function vary considerably throughout the upper and lower gut, but specific population and its diversity for each segment of GI tract is still not well described.

Aims & Methods

Aim: The retrospective evaluation of microorganism population and its diversity separately for upper and lower GI tract by cultivation of tissue samples that were obtained at routine endoscopy of 271 patients indicated to examination for different reasons.
Methods: Biopsies were taken using sterilized standard endoscopic biopsy forceps. Two pieces of tissue were obtained without the removal of forceps from the duodenum, from the antrum of the stomach and in same way from different segments of large intestine. Samples were placed into a 10% glucose solution for microbial cultivation.

Results

Overall, 271 biopsy specimens from the upper and lower GI tract were cultivated, specifically in 235 patients samples were obtained from antrum of stomach and duodenum, in 127 patients from large intestine and in 36 patients from both parts of GI tract. The presence of bacteria in upper GI tract was found in 70,21% and was negative in 29,79% of cases, while in lower GI tract bacteria was found in 93,70% and was negative 6,30% of cases. Tissue samples from both parts of GI tract was obtained from 36 patients and the same genera was found in 44,44%. In upper GI tract E. coli was present in 15,74%, followed by Enterobacter cloacae in 10,64%, Pseudomonas aeruginosa in 8,51%, Enterococcus species in 7,66%, Klebsiella pneumonie subs pneumoniae in 5,11%, Candida albicans in 4,26%, Helicobacter pylori and Klebsiella pneumoniae in 2,98%, Proteus mirabilis in 2,55%, Stenotrophomonas maltofilia in 1,70%, Neisseria subflava and E. coli ESBL positive in 0,85% and 0,43% belongs to Klebsiella pneumoniae ESBL positive, Streptococcus salivarius, Acinetobacter baumani, Staphylococcus warneri, Enterococcus faecalis, Streptococcus maltofilia, Enterococcus hirae and Candida complex. In lower GI tracts E. coli was present in 64,57%, followed by Klebsiella pneumoniae in 8,66%, Candida albicans, Proteus mirabilis and Enterobacter cloacae in 3,15%, Enterococcus species and Klebsiella pneumoniae subs pneumoniae in 2,36%, E. coli ESBL positive, Enterococcus faecalis and Pseudomonas aeruginosa in 1,57%, Candida non albicans and Citrobacter koseri in 0,79%.
The diversity of upper and lower GI tract was measured by Shannon diversity index, and it was 2.48 for upper GI tract and 1.29 for lower GI tract.

Conclusion

Most of studies which reveals fundamental differences between microbiota of upper and lower GI tract is based on examination of luminal content. We are presenting our results of the diversity of microbiota based on cultivation of biopsy samples.

Conference

UEG Week Vienna 2024

Topics

Colorectal

Submission format

Abstract

Session

LOWER GI (Posters)

Citation

United European Gastroenterology Journal 2024; 12 (Supplement 8)

Published

2024

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THE IMPLEMENTATION OF A NEW TYPE OF MERGING ANALYSIS REVEALS THE DYNAMIC INTERACTIONS BETWEEN BACTERIA AND FUNGI IN THE LOWER GASTROINTESTINAL TRACT

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