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FACTORS ASSOCIATED WITH ABDOMINAL PAIN IN PATIENTS WITH ULCERATIVE COLITIS

Tom van Gils 1, Hans Törnblom 1, Börje Jonefjäll 2, Hans Strid 3, Magnus Simrén 1,4

Affiliations

1 University of Gothenburg, Gothenburg, Sweden

2 Sahlgrenska University Hospital, Mölndal, Sweden

3 Karolinska University Hospital, Stockholm, Sweden

4 University of North Carolina at Chapel Hill, Chapel Hill, United States

Summary

AI Generated

Abdominal pain is common in ulcerative colitis patients both during active disease and remission, and is associated with anxiety, depression, fatigue, and reduced quality of life.

In three cohorts of UC patients, 20-39% with active disease and 7-20% in remission reported at least mild abdominal pain.
Patients with abdominal pain had significantly higher rates of anxiety (40-83% vs 7-42%) and depression (33-40% vs 9-13%) compared to those without pain.
Abdominal pain was associated with lower disease-specific quality of life in both active disease and remission, with median IBDQ scores significantly reduced in patients experiencing pain.
In UC patients in remission, abdominal pain was associated with greater impact of fatigue on daily life, with Fatigue Impact Scale scores of 81 versus 29 in those without pain.
The findings suggest that attention to abdominal pain and associated psychological and functional factors may be important for optimizing clinical management of UC patients.

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This summary was generated by an AI large language model based on the content transcript. It is for informational purposes only and should not be considered a substitute for clinical judgment. Always rely on your professional expertise and the full clinical context when making clinical decisions.

Abstract

Introduction

Abdominal pain is a common but often overlooked symptom in patients with ulcerative colitis (UC). The causes of pain during deep remission remain incompletely known, although factors in the brain-gut axis may play a role.

Aims & Methods

The aim of this study was to determine factors associated with abdominal pain in UC patients. Three existing study cohorts of adults with UC were used. Cohort I included 133 patients (49 active), cohort II 287 patients (155 active) and cohort III 92 patients (20 active). The abdominal pain domain of the Gastrointestinal Symptom Rating Scale was used to assess the severity of pain, identifying subjects with at least mild severity of abdominal pain. The Hospital Anxiety and Depression Scale was used to identify subjects with anxiety and or depression (scores ≥8) Patients also completed questionnaires to assess severity of fatigue (Fatigue Impact Scale (FIS, cohort I)), and quality of life (QoL, the IBD questionnaire (IBDQ, cohort II)).

Results

In the three cohorts 39%, 24% and 20% of the patients with active disease and 20%, 7% and 15% of the patients in remission reported at least mild severity of abdominal pain. A higher proportion of UC patients with at least mild abdominal pain had anxiety (83%, 44%, and 40% vs 42%, 18% and 7%; p<0.01) and depression (40%, 33% and 40% vs 13%, 9% and 13% p<0.05). Disease-specific QoL was lower in patients with at least mild abdominal pain, both in patients with active disease (median [IQR] IBDQ score 182 [150-198] vs 144 [115-160], p<0.001) and in remission (IBDQ score 203 [190-213] vs 171 [141-181], p<0.001). In UC patients in remission, having at least mild abdominal pain was associated with more severe impact of fatigue on daily life, (FIS 81 [67-100] versus 29 [14-58], p<0.001).

Conclusion

Abdominal pain is relatively common in patients with UC with active disease as well as in remission. This is associated with anxiety, depression and more severe fatigue and a lower QoL. Hence, paying attention to abdominal pain and associated factors seems important to optimize clinical management of these patients.

Disclosure

Tom van Gils: None
Hans Törnblom: Consultant/Advisory Board member: Cinclus Pharma, Dr Falk Pharma Gmbh, VIPUN Medical.
Speakers’ bureau: Tillotts, Takeda, Galapagos
Börje Jonefjäll: Consultant/advisory board member: Tillots. Speaker for MSD, AbbVie, Tillotts, MEDA, and Takeda.
Hans Strid: Consultant/Advisory Board member: Tillotts, Takeda, Abbvie, Pharmacosmos, BMS
Magnus Simrén: Unrestricted research grants: Glycom/DSM, Genetic Analysis AS
Consultant/Advisory Board member: Danone Nutricia Research, Ironwood, Biocodex, Genetic Analysis AS, Tillotts, Takeda, Arena, Kyowa Kirin, Abbvie, BioGaia, Cinclus Pharma and Pharmanovia.
Speakers’ bureau: Tillotts, Kyowa Kirin, Takeda, Biocodex, Sanofi, Janssen Immunology, Pfizer, Ferrer, BioGaia and Falk Foundation.

Conference

UEG Week Copenhagen 2023

Topics

IBD

Submission format

Abstract

Session

PP 05 IBD (Posters)

Citation

United European Gastroenterology Journal 2023; 11 (Supplement 8)

Published

2023

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THE EFFECT OF INTENSIVE PHYSICAL EXERCISE ON FATIGUE AND QUALITY OF LIFE IN PATIENTS WITH QUIESCENT INFLAMMATORY BOWEL DISEASE: FOLLOW-UP RESULTS OF A MULTICENTRE RANDOMISED CONTROLLED TRIAL (ENERGIZE-IBD TRIAL)

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THE EFFECT OF INTENSIVE PHYSICAL EXERCISE ON FATIGUE AND QUALITY OF LIFE IN PATIENTS WITH QUIESCENT INFLAMMATORY BOWEL DISEASE: FOLLOW-UP RESULTS OF A MULTICENTRE RANDOMISED CONTROLLED TRIAL (ENERGIZE-IBD TRIAL)

Joris J H Hendriks 1,2, Dorien Oomkens 1,2, Jole P. E. van Berlo 1, Liselot van Erp 1, Wendy Heida 1, Jolien P. Wisse 1, Camilo S. Liem 3, Laurens J. W. Kappelle 4, Robert E. H. van Cingel 4,2, Arjan P. J. Kokshoorn 5, Tessa E.H. Römkens 5, Adriaan Tan 6, Willemijn Van Dop 2, Marjolijn Duijvestein 2, Peter J Wahab 1, Marcel J.M. Groenen 1

Affiliations

1 Rijnstate, Arnhem, Netherlands

2 Radboud University Medical Centre, Nijmegen, Netherlands

3 Formupgrade Sports Centre, Arnhem, Netherlands

4 Sport Medisch Centrum Papendal, Arnhem, Netherlands

5 Jeroen Bosch Hospital, 's-Hertogenbosch, Netherlands

6 Canisius Wilhelmina Hospital, Nijmegen, Netherlands