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NEUTROPHIL–LYMPHOCYTE RATIO PREDICTS OVERALL SURVIVAL IN PATIENTS WITH UNRESECTABLE HEPATOCELLULAR CARCINOMA TREATED WITH DURVALUMAB PLUS TREMELIMUMAB: A MULTICENTER ANALYSIS

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NEUTROPHIL–LYMPHOCYTE RATIO PREDICTS OVERALL SURVIVAL IN PATIENTS WITH UNRESECTABLE HEPATOCELLULAR CARCINOMA TREATED WITH DURVALUMAB PLUS TREMELIMUMAB: A MULTICENTER ANALYSIS

HANA OTA 1, Toshifumi Tada 2, Kana Ohmoto 1, Atsushi Hiraoka 3, Hideko Ohama 3, Hidenori Toyoda 4, Kazuya Kariyama 5, Takeshi Hatanaka 6, Kazuhiro Nouso 5, Satoru Kakizaki 7, Takashi Kumada 8, Shinichiro Nakamura 1

Affiliations

1 Japanese Red Cross Society, Himeji, Japan

2 Kobe University Graduate School of Medicine, Kobe, Japan

3 Ehime prefectural Central Hospital, Matsuyama, Japan

4 Ogaki Municipal Hospital, Ogaki, Japan

5 Okayama City Hospital, Okayama, Japan

6 Gunma Saiseikai Maebashi Hospital, Maebashi, Japan

7 NHO Takasaki General Medical Center, Takasaki, Japan

8 Gifu Kyoritsu University, Ogaki, Japan

Summary

AI Generated

Baseline neutrophil-to-lymphocyte ratio ≥2.56 independently predicts poorer overall survival in patients with unresectable hepatocellular carcinoma treated with durvalumab plus tremelimumab.

In 182 patients with unresectable HCC receiving durvalumab (1500 mg every 4 weeks) plus tremelimumab (300 mg single dose), median OS was not reached in the low-NLR group (less than 2.56) versus 12.1 months in the high-NLR group (≥2.56), with NLR ≥2.56 independently predicting poorer OS (HR: 1.919; p = 0.039).
Median PFS was 3.5 months (95% CI: 2.7–4.4 months), and administration of durvalumab plus tremelimumab after second-line treatment independently predicted shorter PFS (HR: 1.819; p = 0.003).
Patients with higher baseline NLR were significantly more likely to receive best supportive care rather than subsequent anticancer therapies after discontinuing durvalumab plus tremelimumab (p = 0.046).
Spline curve analysis identified an optimal NLR threshold range of 2.3–3.0 for OS prediction in this multicenter retrospective cohort treated between May 2022 and June 2024.
No significant differences in immune-related adverse events or treatment response rates were observed between NLR groups.

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Abstract

Introduction

Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide, with limited therapeutic options available for unresectable cases. In recent years, immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape. Among them, the combination of durvalumab (anti-PD-L1) and tremelimumab (anti-CTLA-4), collectively referred to as Dur/Tre, has demonstrated significant survival benefits in patients with advanced HCC. However, robust prognostic biomarkers specific to patients receiving Dur/Tre therapy have yet to be established. The neutrophil-to-lymphocyte ratio (NLR), a systemic marker of inflammation, has been correlated with prognosis in various malignancies, including HCC [1, 2].

Aims & Methods

This study aimed to assess the prognostic significance of baseline NLR in patients with unresectable HCC treated with Dur/Tre. This multicenter retrospective cohort study included 182 patients with unresectable HCC who received Dur/Tre therapy between May 2022 and June 2024. Eligibility criteria included the availability of baseline NLR data and complete clinical records. The treatment regimen comprised a single 300 mg dose of tremelimumab on day 1, followed by 1500 mg of durvalumab administered every four weeks. Primary endpoints were progression-free survival (PFS) and overall survival (OS), assessed using the Kaplan-Meier method and Cox proportional hazards modeling. Baseline NLR values were calculated, and the optimal cutoff for OS prediction was determined using hazard ratio (HR) spline curve analysis.

Results

The median age of patients was 74 years, and 82.9% were male. The median baseline NLR was 3.13. Dur/Tre was administered as first-line therapy in 29.7% of patients and as second-line or later therapy in 70.3%. The median PFS was 3.5 months (95% confidence interval [CI]: 2.7–4.4 months), while the median OS was not reached (95% CI: 12.1 months–not reached). Multivariate analysis identified administration of Dur/Tre after second-line treatment as an independent predictor of shorter PFS (HR: 1.819; p = 0.003). Notably, an NLR ≥2.56 independently predicted poorer OS (HR: 1.919; p = 0.039). Median OS was not reached in the low-NLR group (<2.56), whereas it was 12.1 months in the high- NLR group (≥2.56) (p = 0.016). A Sankey diagram revealed that patients with higher NLR were more likely to receive best supportive care (BSC) rather than subsequent anticancer therapies post-Dur/Tre (p = 0.046). Spline curve analysis identified an optimal NLR threshold range of 2.3–3.0 for OS prediction.

Conclusion

This large, real-world, multicenter study demonstrated that baseline NLR serves as a significant and independent prognostic biomarker for overall survival in patients with unresectable HCC undergoing Dur/Tre therapy. Higher baseline NLR values (≥2.56) were associated with reduced survival and a lower likelihood of receiving subsequent anticancer treatment, whereas patients with lower NLR values were more likely to continue active therapeutic interventions. These findings suggest that NLR may function not only as a prognostic indicator but also as a practical tool for therapeutic decision-making and patient stratification in clinical settings. Further prospective studies with extended follow-up are warranted to validate these findings and refine NLR-based stratification strategies to optimize immunotherapy outcomes in HCC.

References

1. Tada T, Kumada T, Hiraoka A, et al. Neutrophil-to-lymphocyte ratio is associated with survival in patients with unresectable hepatocellular carcinoma treated with Lenvatinib. Liver Int. 2020; 40: 968-976.
2. Tada T, Kumada T, Hiraoka A, et al. Neutrophil-lymphocyte ratio predicts early outcomes in patients with unresectable hepatocellular carcinoma treated with atezolizumab plus bevacizumab: a multicenter analysis. Eur J Gastroenterol Hepatol. 2022; 34: 698-706.

Disclosure

Toshifumi Tada: lecture fees from AbbVie, AstraZeneca, Eisai, and Chugai
Atsushi Hiraoka: lecture fees from Eisai, Bayer, Eli Lilly, and Otsuka
Hidenori Toyoda: lecture fees from AbbVie, Eisai, Gilead, Terumo, and Bayer

Event

UEG Week Berlin 2025

Topics

Hepatobiliary Immunology Mechanisms & Personalised Medicine

Submission format

Abstract

Session

Bench to bedside and beyond frontiers in HCC

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

THE EFFECT OF A NATIONAL TRAINING PROGRAMME FOR SEDATION AND EMERGENCY MANAGEMENT IN ENDOSCOPY

Ulrike Beilenhoff

FROM STOOL TO SCOPE: OPTIMISING FIT THRESHOLDS TO GUIDE FUTURE PANENTERIC CAPSULE ENDOSCOPY AND REDUCE COLONOSCOPY BURDEN IN IRON DEFICIENCY ANAEMIA

Kiara McDonnell

Where is my chest pain coming from?!

Isabella Dulmin

A PROSPECTIVE STUDY COMPARING ULTRA-LOW VOLUME BOWEL PREPARATIONS FOR CAPSULE COLONOSCOPY AND PAN-INTESTINAL CAPSULE ENDOSCOPY: EFFICACY OF 1L POLYETHYLENE GLYCOL PLUS ASCORBIC ACID VS. SODIUM PICOSSULFATE WITH MAGNESIUM CITRATE

José Berkeley Cotter

Treatment of patients with ingestion of caustic substances

Nikolaos Samarentsis

THE FUTURE OF DIGESTIVE CARE: NURSE COACH AND NEW TECHNOLOGIES IN FUNCTIONAL NEUROGASTROENTEROLOGY

Maite Herraiz Bayod

UEG Presentation

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THE EFFECT OF A NATIONAL TRAINING PROGRAMME FOR SEDATION AND EMERGENCY MANAGEMENT IN ENDOSCOPY

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THE EFFECT OF A NATIONAL TRAINING PROGRAMME FOR SEDATION AND EMERGENCY MANAGEMENT IN ENDOSCOPY

Ulrike Beilenhoff 1

Affiliations

1 ESGENA Scientific Secretary, Ulm, Germany

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Abstract

Introduction

Since 2029 national curricula for sedation and emergency management in endoscopy has established for endoscopy staff. NAPS are trained in three-day courses. After a baseline assessment in 2013, the effect of the training was evaluated in a survey in 2018.

Results & Findings

The questionnaire was completed by 356 endoscopy departments (95% in hospitals, 6% in private practice).

Most departments operate in a multidisciplinary manner (85% gastroenterology, 59% TEE, 13% cardiology, 1.12% urology).
In 52% of departments, 100% of staff have been trained, while 30% have trained 75-100% of staff. Refresher courses are completed every 2-5 years by 77% of units, while annual resuscitation courses are established in 93% od units.
98% have examination rooms equipped with BB, pulse oximeter, ECG, and oxygen supply. The second suction is available in 80%, and capnography in 9%. 83% have their own recovery room, 16% use other recovery rooms.
ASA classification is used in 80% of unit for risk assessment, while Mallampati score is used in 7% only. 38% developed department specific scores. 63% perform the sign-in for all patients, 16% for 75-100% of patients. Only 10% of departments never perform a sign-in.
35% of units perform team-time-out (TTO) for all patients, 11% for 75-100% of patients. Only 26% of departments never use TTO.
In 47% of departments, a dedicated person for patient monitoring and sedation is available. 30% have this person in 75-100% of patients, and 14% have this person in 25-50% of cases.
Propofol mono sedation by bolus application is used in 88% of units, TCI in 17% of units, combination Propofol and Midazolam is used in 27%.
In 77% of units, inpatients and outpatient are equally monitored in the recovery area while 21% of units only use the recovery area for outpatients.
In 73% of units, physicians discharge the patient, in 12% nurses discharge patients.
In 80% of departments, patients are only allowed to leave the endoscopy with an accompanying person.
70% of departments document all complications, but only 42% evaluate the complication rate statistically.
42% of units reported to have no problems to establish all requirements for sedation and patient monitoring. 37% reported about staff shortage. 12% could not find new staff, 25% reported about financial problems. 44% reported about resistance in their own department or with hospital management to establish improvements.

Summary & Discussion

Comparing data from 2013, 2018 and 2024, improvements could be identified in the establishment of riss assessment by using ASA Score and individual checklists, Malampati score is still not well-known. The establishment of TTO increased from 20 to 35% in all patients, but still needs to be improved.
The availability of a sedating person remains unchanged with 40 to 47% in all patients and 30% in 75-100% of patients. The recovery situation remains unchanged.

Conclusion

Staff shortage and resistance within the own team are the main challenges when establishing safe sedation and patient monitoring in Endoscopy.

Disclosure

no conflict of interest

Event

UEG Week Berlin 2025

Topics

Nurses

Submission format

Abstract

Session

Abstracts I: Management and education

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

THE EFFECT OF A NATIONAL TRAINING PROGRAMME FOR SEDATION AND EMERGENCY MANAGEMENT IN ENDOSCOPY

Ulrike Beilenhoff

FROM STOOL TO SCOPE: OPTIMISING FIT THRESHOLDS TO GUIDE FUTURE PANENTERIC CAPSULE ENDOSCOPY AND REDUCE COLONOSCOPY BURDEN IN IRON DEFICIENCY ANAEMIA

Kiara McDonnell

Where is my chest pain coming from?!

Isabella Dulmin

A PROSPECTIVE STUDY COMPARING ULTRA-LOW VOLUME BOWEL PREPARATIONS FOR CAPSULE COLONOSCOPY AND PAN-INTESTINAL CAPSULE ENDOSCOPY: EFFICACY OF 1L POLYETHYLENE GLYCOL PLUS ASCORBIC ACID VS. SODIUM PICOSSULFATE WITH MAGNESIUM CITRATE

José Berkeley Cotter

Treatment of patients with ingestion of caustic substances

Nikolaos Samarentsis

THE FUTURE OF DIGESTIVE CARE: NURSE COACH AND NEW TECHNOLOGIES IN FUNCTIONAL NEUROGASTROENTEROLOGY

Maite Herraiz Bayod

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

FROM STOOL TO SCOPE: OPTIMISING FIT THRESHOLDS TO GUIDE FUTURE PANENTERIC CAPSULE ENDOSCOPY AND REDUCE COLONOSCOPY BURDEN IN IRON DEFICIENCY ANAEMIA

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FROM STOOL TO SCOPE: OPTIMISING FIT THRESHOLDS TO GUIDE FUTURE PANENTERIC CAPSULE ENDOSCOPY AND REDUCE COLONOSCOPY BURDEN IN IRON DEFICIENCY ANAEMIA

Ian Io Lei 1, Nicola O'Connell 2, Michael Adu-Darko 3, Jessiya Parambil 4, Vishnupriya Suresh 2, Kiara McDonnell 5, Jessie Newville 5, Kirsten Chaplin 5, Deekshi Siyambalapityage 5, Asad Khan 3, Usman Muhammad 3, John Emil 3, Merali Abbas 3, Zia Kanji 3, Hamza Alam 3, Amelia Bennett 4, Hannah Soanes 4, Adrija Bhattacharyya 4, Karl Frey 4, Rosie Meakins 4, Archit Singhal 4, George Pack 4, Melike Gerrits 4, Harry Paterson 4, Vincent Cheung 6, Sue Cullen 5, Muhammad Imran Aslam 7, Ramesh P. Arasaradnam 2

Affiliations

1 University Hospital of Coventry and Warwickshire, Coventry, United Kingdom

2 University Hospital Coventry and Warwickshire, Coventry, United Kingdom

3 Milton Keynes University Hospital,, Milton Keynes, United Kingdom

4 Oxford University Hospital, Oxford, United Kingdom

5 Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Aylesbury, United Kingdom

6 John Radcliffe Hospital, Oxford, United Kingdom

7 University Hospitals of Coventry and Warwickshire, Coventry, United Kingdom

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Abstract

Introduction

Colon capsule endoscopy (CCE) or panenteric capsule endoscopy (PCE) offers a promising, non-invasive diagnostic approach for patients with iron deficiency anaemia (IDA). However, high rates of conversion to conventional colonoscopy (CCC) following capsule procedures reduce cost-effectiveness and patient satisfaction. Optimising the faecal immunochemical test (FIT) threshold may improve patient stratification and reduce unnecessary conversions in future applications within the IDA diagnostic pathway.

Aims & Methods

This study aimed to evaluate the accuracy of faecal immunochemical testing (FIT) in predicting colorectal cancer (CRC) and polyp burden in patients with iron deficiency anaemia (IDA), and to extrapolate these findings to assess FIT’s utility in predicting the likelihood of conversion from CCE to conventional colonoscopy (CCC) based on underlying pathology in IDA.
The CLEAR IDA study was a multicentre, retrospective observational study conducted across four UK hospitals. Data were collected over a six-month study period and included patients referred via the two-week-wait (2WW) cancer pathway for iron deficiency, with or without anaemia, over a 12-month timeframe. Colonoscopy findings were analysed and extrapolated using NHS England’s CCE-to-colonoscopy referral criteria to assess the predictive value of FIT for colorectal cancer (CRC), polyp burden, and CCC using ROC curve analysis. The optimal FIT threshold was identified through three complementary approaches: threshold-based analysis, decision curve analysis, and cost-benefit modelling.

Results

A total of 1,531 patients were analysed; only 1.6% underwent small bowel capsule endoscopy. The diagnostic accuracy (AUC) of FIT for predicting CRC, polypoidal lesions, and CCC was 0.78, 0.58, and 0.69, respectively. Threshold-based analysis identified FIT = 15 µg/g as the lowest level at which CCC rates significantly increased (p = 0.02; OR = 1.87; 95% CI: 1.07–3.14). Decision curve analysis showed maximum net benefit at FIT = 17.6 µg/g, while cost-benefit modelling identified 9 µg/g as the most cost-effective. An optimal cost-effective FIT threshold range was identified between 10 and 17.6 µg/g. Threshold selection should be tailored to local service capacity and resource availability.

Conclusion

Significant pathologies in the IDA pathway were uncommon. A FIT threshold range between 10–17 µg/g may enhance cost-effectiveness and guide appropriate PCE use in IDA.

References

1) Snook J, Bhala N, Beales ILP, et al. British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults. Gut. 2021 Nov;70(11):2030-2051.
2) (NICE) NIFHACE. PillCam COLON 2 for investigation of the colon through direct visualisation: NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE; August 2024 [cited 2025 23/03/2025]; Diagnostics Assessment Programme]. Available from: https://www.nice.org.uk/guidance/gid-dg10083/documents/final-scope-2
3) Turvill J, Haritakis M, Pygall S, et al. Multicentre Study of 10,369 Symptomatic Patients Comparing the Diagnostic Accuracy of Colon Capsule Endoscopy, Colonoscopy and CT Colonography. Aliment Pharmacol Ther. 2025 Feb 26;0:1–13.
4) Cilona A, Zullo A, Hassan C, et al. Is faecal-immunochemical test useful in patients with iron deficiency anaemia and without overt bleeding? Dig Liver Dis. 2011 Dec;43(12):1022-4.
5) Turvill JL, Turnock D, Cottingham D, et al. The Fast Track FIT study: diagnostic accuracy of faecal immunochemical test for haemoglobin in patients with suspected colorectal cancer. Br J Gen Pract. 2021 Aug;71(709):e643-e651.

Event

UEG Week Berlin 2025

Topics

Endoscopy Radiology & Imaging

Submission format

Abstract

Session

Advances in the investigation of the small bowel

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

THE EFFECT OF A NATIONAL TRAINING PROGRAMME FOR SEDATION AND EMERGENCY MANAGEMENT IN ENDOSCOPY

Ulrike Beilenhoff

FROM STOOL TO SCOPE: OPTIMISING FIT THRESHOLDS TO GUIDE FUTURE PANENTERIC CAPSULE ENDOSCOPY AND REDUCE COLONOSCOPY BURDEN IN IRON DEFICIENCY ANAEMIA

Kiara McDonnell

Where is my chest pain coming from?!

Isabella Dulmin

A PROSPECTIVE STUDY COMPARING ULTRA-LOW VOLUME BOWEL PREPARATIONS FOR CAPSULE COLONOSCOPY AND PAN-INTESTINAL CAPSULE ENDOSCOPY: EFFICACY OF 1L POLYETHYLENE GLYCOL PLUS ASCORBIC ACID VS. SODIUM PICOSSULFATE WITH MAGNESIUM CITRATE

José Berkeley Cotter

Treatment of patients with ingestion of caustic substances

Nikolaos Samarentsis

THE FUTURE OF DIGESTIVE CARE: NURSE COACH AND NEW TECHNOLOGIES IN FUNCTIONAL NEUROGASTROENTEROLOGY

Maite Herraiz Bayod

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

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Where is my chest pain coming from?!

Isabella Dulmin 1

Affiliations

1 University of Pisa, Pisa, Italy

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Abstract

Event

UEG Postgraduate Teaching Programme Berlin 2025

Topics

Oesophagus

Session

Non-cardiac chest pain: The tale of a sore oesophagus

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

THE EFFECT OF A NATIONAL TRAINING PROGRAMME FOR SEDATION AND EMERGENCY MANAGEMENT IN ENDOSCOPY

Ulrike Beilenhoff

FROM STOOL TO SCOPE: OPTIMISING FIT THRESHOLDS TO GUIDE FUTURE PANENTERIC CAPSULE ENDOSCOPY AND REDUCE COLONOSCOPY BURDEN IN IRON DEFICIENCY ANAEMIA

Kiara McDonnell

Where is my chest pain coming from?!

Isabella Dulmin

A PROSPECTIVE STUDY COMPARING ULTRA-LOW VOLUME BOWEL PREPARATIONS FOR CAPSULE COLONOSCOPY AND PAN-INTESTINAL CAPSULE ENDOSCOPY: EFFICACY OF 1L POLYETHYLENE GLYCOL PLUS ASCORBIC ACID VS. SODIUM PICOSSULFATE WITH MAGNESIUM CITRATE

José Berkeley Cotter

Treatment of patients with ingestion of caustic substances

Nikolaos Samarentsis

THE FUTURE OF DIGESTIVE CARE: NURSE COACH AND NEW TECHNOLOGIES IN FUNCTIONAL NEUROGASTROENTEROLOGY

Maite Herraiz Bayod

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

A PROSPECTIVE STUDY COMPARING ULTRA-LOW VOLUME BOWEL PREPARATIONS FOR CAPSULE COLONOSCOPY AND PAN-INTESTINAL CAPSULE ENDOSCOPY: EFFICACY OF 1L POLYETHYLENE GLYCOL PLUS ASCORBIC ACID VS. SODIUM PICOSSULFATE WITH MAGNESIUM CITRATE

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

A PROSPECTIVE STUDY COMPARING ULTRA-LOW VOLUME BOWEL PREPARATIONS FOR CAPSULE COLONOSCOPY AND PAN-INTESTINAL CAPSULE ENDOSCOPY: EFFICACY OF 1L POLYETHYLENE GLYCOL PLUS ASCORBIC ACID VS. SODIUM PICOSSULFATE WITH MAGNESIUM CITRATE

Joao Carlos Goncalves 1, Ines Marques 1, Mariana Souto 1, Ana Isabel Ferreira 1, Joana Lúcia Teixeira Magalhães Magalhães 1, Bruno Rosa 1, José Berkeley Cotter 1

Affiliations

1 Unidade Local de Saúde do Alto Ave, Guimarães, Portugal|||Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal

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Abstract

Introduction

Capsule colonoscopy and Pan-intestinal Capsule Endoscopy (PCE) are well-established diagnostic procedures. However, the optimal bowel preparation regimen remains undefined, with pooled adequate cleansing rates reaching only 72.5%¹. While ultra-low volume preparations (≤1L) have demonstrated efficacy in conventional colonoscopy², their effectiveness in capsule-based modalities has yet to be determined.

Aims & Methods

In this prospective, randomized, researcher-blind, single center trial, we compared the efficacy of two ultra-low volume bowel preparation regimens, 1L Polyethylene Glycol Plus Ascorbic Acid (PEG-Asc) and 1L Sodium Picossulfate with Magnesium Citrate (SPMC). Patients referred for capsule-based procedures were randomized in a 1:1 ratio to receive either PEG-Asc or SPMC. The primary endpoints were the rates of complete examinations, adequate bowel preparation, and excellent right colon cleansing.

Results

A total of 117 patients were included, referred for capsule colonoscopy due to incomplete colonoscopy (76.1%) or for PCE to assess luminal inflammation (17.9%) or anemia (6%). Overall, 61.5% were female, with a mean age of 61.3 ± 16 years. The complete examination rate was 71.8%, with no significant difference between groups (PEG-Asc 72.9% vs. SPMC 70.7%; p = 0.792). Adequate bowel preparation was achieved in 62.4% of cases, which was significantly more frequent in the PEG-Asc group (72.9%) compared to SPMC (51.7%; p = 0.018). Among complete procedures, excellent right colon cleansing was observed more often with PEG-Asc (34.1%) than with SPMC (7.3%; p = 0.003).

Conclusion

The completion and adequate preparation rates remain suboptimal in the capsule colonoscopy and PCE procedures. In this study, both ultra-low volume purgative solutions demonstrated comparable efficacy in achieving complete examinations, but the PEG-Asc resulted in significantly better overall preparation quality and superior right colon cleansing compared to SPMC. These findings suggest that PEG-Asc may be the preferred ultra-low volume regimen for optimizing bowel visualization in capsule-based examinations.

References

1. Rosa, B., Donato, H., Cúrdia Gonçalves, T., Sousa-Pinto, B. & Cotter, J. What Is the Optimal Bowel Preparation for Capsule Colonoscopy and Pan-intestinal Capsule Endoscopy? A Systematic Review and Meta-Analysis. Dig. Dis. Sci. 68, 4418–4431 (2023).
2. Arieira, C. et al. Bowel cleansing efficacy for colonoscopy: prospective, randomized comparative study of same-day dosing with 1-L and 2-L PEG + ascorbate. Endosc. Int. Open 09, E1602–E1610 (2021).

Event

UEG Week Berlin 2025

Topics

Endoscopy Radiology & Imaging Colorectal

Submission format

Abstract

Session

Advances in the investigation of the small bowel

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

THE EFFECT OF A NATIONAL TRAINING PROGRAMME FOR SEDATION AND EMERGENCY MANAGEMENT IN ENDOSCOPY

Ulrike Beilenhoff

FROM STOOL TO SCOPE: OPTIMISING FIT THRESHOLDS TO GUIDE FUTURE PANENTERIC CAPSULE ENDOSCOPY AND REDUCE COLONOSCOPY BURDEN IN IRON DEFICIENCY ANAEMIA

Kiara McDonnell

Where is my chest pain coming from?!

Isabella Dulmin

A PROSPECTIVE STUDY COMPARING ULTRA-LOW VOLUME BOWEL PREPARATIONS FOR CAPSULE COLONOSCOPY AND PAN-INTESTINAL CAPSULE ENDOSCOPY: EFFICACY OF 1L POLYETHYLENE GLYCOL PLUS ASCORBIC ACID VS. SODIUM PICOSSULFATE WITH MAGNESIUM CITRATE

José Berkeley Cotter

Treatment of patients with ingestion of caustic substances

Nikolaos Samarentsis

THE FUTURE OF DIGESTIVE CARE: NURSE COACH AND NEW TECHNOLOGIES IN FUNCTIONAL NEUROGASTROENTEROLOGY

Maite Herraiz Bayod

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Treatment of patients with ingestion of caustic substances

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Treatment of patients with ingestion of caustic substances

Aga Charitini 1, Nikolaos Samarentsis 1

Affiliations

1 None, None, Greece

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Abstract

Event

UEG Week Berlin 2025

Topics

Nurses

Session

Endoscopic techniques: Emergency and difficult situations

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

THE EFFECT OF A NATIONAL TRAINING PROGRAMME FOR SEDATION AND EMERGENCY MANAGEMENT IN ENDOSCOPY

Ulrike Beilenhoff

FROM STOOL TO SCOPE: OPTIMISING FIT THRESHOLDS TO GUIDE FUTURE PANENTERIC CAPSULE ENDOSCOPY AND REDUCE COLONOSCOPY BURDEN IN IRON DEFICIENCY ANAEMIA

Kiara McDonnell

Where is my chest pain coming from?!

Isabella Dulmin

A PROSPECTIVE STUDY COMPARING ULTRA-LOW VOLUME BOWEL PREPARATIONS FOR CAPSULE COLONOSCOPY AND PAN-INTESTINAL CAPSULE ENDOSCOPY: EFFICACY OF 1L POLYETHYLENE GLYCOL PLUS ASCORBIC ACID VS. SODIUM PICOSSULFATE WITH MAGNESIUM CITRATE

José Berkeley Cotter

Treatment of patients with ingestion of caustic substances

Nikolaos Samarentsis

THE FUTURE OF DIGESTIVE CARE: NURSE COACH AND NEW TECHNOLOGIES IN FUNCTIONAL NEUROGASTROENTEROLOGY

Maite Herraiz Bayod

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

THE FUTURE OF DIGESTIVE CARE: NURSE COACH AND NEW TECHNOLOGIES IN FUNCTIONAL NEUROGASTROENTEROLOGY

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

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THE FUTURE OF DIGESTIVE CARE: NURSE COACH AND NEW TECHNOLOGIES IN FUNCTIONAL NEUROGASTROENTEROLOGY

Beatriz Oses 1, Adriana Arregui-Azagra 1, Beatriz Gil-Albert Sáenz de Cabezón 2, María Teresa Alonso Sierra 2, Susana de la Riva 1, Maite Herraiz Bayod 1

Affiliations

1 Clinica Universidad de Navarra, Pamplona, Spain

2 Clinica Universidad de Navarra, Madrid, Spain

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Abstract

Introduction

Functional gastrointestinal disorders (FGIDs), such as irritable bowel syndrome (IBS) and functional dyspepsia, are prevalent conditions within the field of Neurogastroenterology. These disorders have a profound impact on patients’ quality of life and demand a comprehensive biopsychosocial approach to care. Despite evidence in favor of integrated care, treatment remains largely pharmacological. To address this gap, our hospital established a dedicated Functional Neurogastroenterology Unit by incorporating a nurse trained in health coaching and Neuro-Linguistic Programming (NLP) supported by a custom GPT-based artificial intelligence (AI) tool aimed at enhancing patient communication and clinical decision-making.

Results & Findings

A descriptive observational study was conducted on nurse-led consultations between September 2024 and April 2025. The intervention integrated coaching sessions, Neuro-Linguistic Programming (NLP), and the use of a customized GPT-based system to support communication and care planning. Data collected included demographic characteristics, presenting symptoms, and referral patterns. Additionally, each patient was invited to write a personal narrative reflecting on their experience throughout the intervention.

Summary & Discussion

Forty-eight patients were attended during the study period (mean age: 38.6 years; 68.7% female). The most common diagnoses were functional dyspepsia, irritable bowel syndrome, and nonspecific digestive disorders. Frequently reported symptoms included bloating, epigastric pain, early satiety and burning. 20.8% of patients were referred to psychology services and 2.1% to psychiatry. Patient narratives revealed improvements in emotional self-regulation, greater sense of empowerment, and high levels of satisfaction. AI reduced administrative burden, improving focus on direct care, interdisciplinary communication, and adherence to treatment.

Conclusion

Coaching, NLP and AI are effective tools to address FGIDs from nursing, promoting personalized care and improving the patient's emotional well-being.

References

1.Alenazi, S. K., et al. (2024). Integrating Artificial Intelligence Technologies into Nursing Practice: Revolutionizing Patient Care and Healthcare Efficiency. Journal of International Crisis & Risk Communication Research (JICRCR), 7.
2.Barr, J. A., & Tsai, L. P. (2021). Health coaching provided by registered nurses described: a systematic review and narrative synthesis. BMC nursing, 20, 1-18.
3.Vitale, E., & Germini, F. (2021). Nurse coaching improves healthy conditions: an integrative review of the literature. Italian Journal of Medicine, 15(3).
4.Thomas, J. (2025). Artificial intelligence in nursing research: A narrative review of transforming clinical practice, enhancing patient outcomes, and shaping future care. decision-making, 1, 3.
5. Feingold JH, Drossman DA. Deconstructing stigma as a barrier to treating DGBI: Lessons for clinicians. Neurogastroenterol Motil. 2021 Feb;33(2):e14080. doi:10.1111/nmo.14080. Epub 2021 Jan 23.
6.Zia JK, Lenhart A, Yang PL, Heitkemper MM, Baker J, Keefer L, et al. Risk factors for abdominal pain-related disorders of gut-brain interaction in adults and children: A systematic review. Gastroenterology. 2022 Oct;163(4):995-1023.e3. doi:10.1053/j.gastro.2022.06.028. Epub 2022 Jun 16.
7.Alonso-Sierra M, Malagelada C, Serra J. Organization of Neurogastroenterology and Motility units with a multidisciplinary, patient-centered perspective. Rev Esp Enferm Dig. 2024 Jun;116(6):302-304. doi:10.17235/reed.2024.10368/2024.

Event

UEG Week Berlin 2025

Topics

Nurses

Submission format

Abstract

Session

Abstracts II: Patient care and endoscopic techniques

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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