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Introduction

Several biomarkers including adipokines have been investigated in chronic pancreatitis (CP). Nevertheless, the current results are inconclusive with conflicting results.

Aims & Methods

Therefore, we aimed to evaluate the levels of major adipokines including adiponectin, leptin, and resistin in CP patients. A systematic electronic search using Pubmed, Embase, and Scopus was conducted, evaluating observational studies published till November 2022. Quality assessment of the included studies was performed using the Newcastle-Ottawa Scale (NOS). The principal summary outcome was the mean difference (MD). Results were reported as MD (95% confidence interval [CI]).

Results

A total of 14 studies were included in our qualitative synthesis, out of which, 9 were evaluated in our quantitative synthesis. A significant MD in leptin levels was found in CP patients vs. controls (-1.299 [95% CI -2.493 – 0.105]), resistin levels in CP patients vs. controls (10.129 [95% CI 6.735 – 13.524]), and adiponectin levels in pancreatic cancer (PC) patients vs. controls (11.240 [95% CI 5.872 – 16.60]). Nevertheless, no significant MD was observed in leptin levels between CP vs. PC patients (-1.299 [95% CI -2.493 – 0.105]), in addition to adiponectin levels in CP patients vs. controls (0.422 [95% CI -5.651 – 6.535]) and CP vs. PC patients (-6.252 [95% CI -13.269 – 0.766]).

Conclusion

We reported significantly decreased leptin and increased resistin levels in CP patients. Moreover, PC patients present increased levels of adiponectin. However, leptin and adiponectin levels did not significantly differ between CP and PC patients, as well as adiponectin levels between CP patients and controls.

DO ADIPOKINES PLAY A ROLE IN CHRONIC PANCREATITIS? A SYSTEMATIC REVIEW AND META-ANALYSIS

Abdulrahman Ismaiel 1, Max-Ludwig Kiessling 1, Mohamed Ismaiel 2, Nahlah Al Srouji 1, Daniel-Corneliu Leucuta 1, Popa Stefan-Lucian 1, Dan Lucian Dumitrascu 1

1 "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania

2 Altnagelvin Hospital, Londonderry, United Kingdom

Conference

UEG Week Copenhagen 2023

Topics

Pancreas

Submission format

Abstract

Session

PP 08 Pancreas (Posters)

Citation

United European Gastroenterology Journal 2023; 11 (Supplement 8)

Published

2023

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Introduction

The consequences of chronic pancreatitis (CP) may not be exclusively limited to the pancreas or restricted to the gastrointestinal tract but could also be systemic. To date, the relationship between chronic pancreatitis and cardiovascular risk factors has not been studied extensively. We conducted a systematic review and meta-analysis to examine if the combination of chronic inflammatory changes may possibly place CP patients at risk for cardiovascular disease.

Aims & Methods

We systematically searched PubMed, Scopus, and Cochrane Register of Controlled Trials for observational studies that compared major cardiovascular outcomes in patients with chronic pancreatitis. The outcomes explored were: (1) acute coronary disease/myocardial infarction; (2) hypertension; (3) hyperlipidemia; and (4) diabetes mellitus. We computed odds ratio (OR) for binary endpoints, with 95% confidence intervals (CI). Heterogeneity was examined I² statistics; p values less than 0.10 and I² > 25% were considered significant for heterogeneity.

Results

Four observational studies comprising a total of 57,721 patients with chronic pancreatitis were included in this meta-analysis. The most consistent finding across studies was a significantly higher risk of diabetes mellitus in patients with chronic pancreatitis compared to a control group without chronic pancreatitis (OR 4.77; 95% CI 1.32–17.28; p=0.017; I²=100%). In contrast, no statistically significant associations were found between chronic pancreatitis and other cardiovascular outcomes, including cerebrovascular disease (OR 1.59; 95% CI 0.98–2.57; p=0.05; I²=99.4%), acute coronary syndrome/myocardial infarction (OR 1.35; 95% CI 1.00–1.82; p=0.049; I²=95.4%), hypertension (OR 0.52; 95% CI 0.30–7.61; p=0.608; I²=99.9%) or hyperlipidemia (OR 2.60; 95% CI 0.36–18.77; p=0.342; I²=100%).

Conclusion

The results of our meta-analysis suggest that chronic pancreatitis is not associated with increased risk of cardiovascular disease despite being associated with a higher risk of diabetes mellitus.

CARDIOVASCULAR RISK IN PATIENTS WITH CHRONIC PANCREATITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Bruna Cerbino 1, Gabriel Gomes Lopes 2, Milena Tomé 3, Assaina Tatiana Jaquissone Tomo 4, Aluisio D’lucas Alves e Gomes 2, David Abraham Da Hora 5

1 Pró-Cardíaco Hospital, Rio de Janeiro, Brazil

2 Federal University of Ceará, Fortaleza, Brazil

3 Federal University of Campina Grande, Cajazeiras, Brazil

4 Eduardo Mondlane University, Maputo, Mozambique

5 Federal University of Amazonas, Manaus, Brazil

Conference

UEG Week Berlin 2025

Topics

Pancreas

Submission format

Abstract

Session

Chronic pancreatic disease: Pancreatitis and cystic fibrosis (Posters)

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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Introduction

Pancreatic calcification is the most frequent structural change in chronic pancreatitis (CP), but the factors associated with its development are not well understood.

Aims & Methods

We aimed to investigate the risk factors of calcification development in patients with chronic pancreatitis. The study protocol was registered on PROSPERO (CRD42024591837). On September 18, 2024, we conducted a systematic search across three databases (PubMed, EMBASE, and CENTRAL) for studies reporting factors associated with calcification in chronic pancreatitis (CP). Pooled proportions and odds ratios (OR) with 95% confidence intervals (CI) were calculated using a random effects model.

Results

The systematic search resulted in 10,893 articles, from which 85 eligible studies were identified, covering a total of 34568 participants. The odds of calcification were 45% higher in alcoholic compared to idiopathic CP (OR=1.45, CI: 1.00–2.11). Alcohol consumption (OR=2.31, CI: 1.8–2.98) and smoking (OR=2.22, CI: 1.61–3.06) were associated with a two times higher risk of calcification in CP, when compared to non-smokers and non-drinkers. In contrast, the presence of CFTR mutations did not increase the risk of calcification in CP (OR=0.43, CI: 0.11–1.66) compared to patients without CFTR mutations.

Conclusion

Alcohol consumption and smoking were significantly associated with the presence of calcification in CP, making it essential to identify these risk factors and incorporate smoking cessation and alcohol reduction programs into standard care.

RISK FACTORS OF CALCIFICATION IN CHRONIC PANCREATITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Orsolya Eperjesi 1, Jazmin Nemeth 2, Anett Rancz 2, Dániel Sándor Veres 3, Brigitta Teutsch 4, Renáta Papp 2, Peter Hegyi 5, Stefania Bunduc 6

1 Centre for Translational Medicine, Semmelweis University, Budapest, Hungary|||Toldy Ferenc Hospital, Cegléd, Hungary

2 Centre for Translational Medicine, Semmelweis University, Budapest, Hungary

3 Centre for Translational Medicine, Semmelweis University, Budapest, Hungary|||Semmelweis University, Budapest, Hungary

4 Centre for Translational Medicine, Semmelweis University, Budapest, Hungary|||Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary

5 Centre for Translational Medicine, Semmelweis University, Budapest, Hungary|||Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary

6 Centre for Translational Medicine, Semmelweis University, Budapest, Hungary|||Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Conference

UEG Week Berlin 2025

Topics

Pancreas

Submission format

Abstract

Session

PANCREAS (Posters)

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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Introduction

Chronic pancreatitis (CP) is a progressive inflammatory disorder that predisposes patients to various complications, including vascular events. Among these, splenic vein thrombosis (SVT) represents a siginficant, but often underdiagnosed complication, with reported prevalence rates varying widely. SVT may lead to sinistral portal hypertension, resulting in gastric varices and, in severe cases, life-threatening gastrointestinal hemorrhage. This systematic review and meta-analysis aims to determine the true pooled prevalence of SVT in CP patients and to evaluate the bleeding rate among those with splenic thrombosis by synthesizing data from studies in which all participants underwent appropriate imaging for SVT detection.

Aims & Methods

An exploratory search was conducted to identify key articles reporting on the prevalence of SVT among CP patients. Four studies were selected based on their provision of relevant, poolable data on prevalence with the use of proper imaging techniques for detecting SVT, encompassing a total of 1,973 patients. A random effects meta‐analysis was performed using SPSS, and a forest plot was genrated to visually represent both individual and overall prevalence estimates. An ongoing PRISMA compliant systematic literature search continues to capture all pertinent studies on this topic.

Results

Analysis of data from the four selected studies (n = 1,973) revealed a pooled SVT prevalence of 12.7% in CP patients. Although individual study estimates varied, likely reflecting differences in study design, CP etiology, and follow-up duration, the overall result indicates that approximately one in eight patients with CP develops SVT.

Conclusion

Our preliminary findings demonstrate that, when appropriate imaging is employed, SVT occurs in approximately 12.7% of chronic pancreatitis cases. These results underscore the clinical importance of SVT, particularly given its association with an increased risk of gastrointestinal hemorrhage. Routine evaluation for SVT in CP patients should be considered, and further research is warranted to elucidate underlying risk factors and to refine management strategies for this potentially life-threatening vascular complication.

SPLENIC VEIN THROMBOSIS PREVALENCE IN CHRONIC PANCREATITIS: A SYSTEMATIC REVIEW AND META‐ANALYSIS

Ruben Zsolt Borbély 1, Jakub Hoferica 2, Brigitta Teutsch 3, Eszter Ágnes Szalai 4, Peter Jeno Hegyi 5, Balint Eross 3, Nándor Faluhelyi 6, Peter Hegyi 7

1 Semmelweis University, Budapest, Hungary|||Bajcsy-Zsilinszky Hospital, Budapest, Hungary

2 Semmelweis University, Budapest, Hungary|||Comenius University, Martin, Slovakia

3 Semmelweis University, Budapest, Hungary|||Semmelweis University, Budapest, Hungary|||University of Pecs, Pecs, Hungary

4 Semmelweis University, Budapest, Hungary

5 Semmelweis University, Budapest, Hungary|||Semmelweis University, Budapest, Hungary

6 Semmelweis University, Budapest, Hungary|||University of Pecs, Pecs, Hungary

7 Semmelweis University, Budapest, Hungary|||University of Pecs, Pecs, Hungary|||University of Szeged, Szeged, Hungary

Conference

UEG Week Berlin 2025

Topics

Pancreas

Submission format

Abstract

Session

PANCREAS (Posters)

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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Introduction

Acute pancreatitis (AP) can progress to recurrent acute pancreatitis (RAP) or chronic pancreatitis (CP).

Aims & Methods

This systematic review and meta-analysis aimed to identify risk factors associated with this progression. The protocol was registered on PROSPERO (CRD42022368931). A comprehensive search was conducted in three (Medline, Embase, Cochrane) databases on October 25th, 2022. Articles reporting and risk factors associated with AP progression into RAP or CP were included. Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using the random effects model. Heterogeneity was evaluated using the I² statistic. The risk of bias assessment was performed using the Quality in Prognostic Studies (QUIPS) tool.

Results

A total of 71 articles were included in the meta–analysis, and several risk factors were identified for the progression of AP into RAP and CP. We found the following risk factors of AP recurrence: younger age, male gender, smoking, alcoholic etiology, hypertriglyceridemia, diabetes mellitus, pseudocyst, etc. The pooled OR for the male gender was 1.45 (95% CI: 1.29-1.64, I²=24%), for smoking was 1.45 (95% CI: 1.16-1.81, I²=62%), for alcoholic etiology was 1.76 (95% CI: 1.38-2.25, I²=81%), for hypertriglyceridemia was 2.45 (95% CI: 2.07-2.90, I²=9%), for diabetes mellitus was 1.49 (95% CI: 1.24-1.80, I²=0%), for pseudocyst was 2.19 (95% CI: 1.52-3.15, I²=0%). We also found risk factors of RAP progression into CP. The risk of bias was moderate in the majority of the included studies.

Conclusion

Our study identified multiple modifiable risk factors which can be treated to prevent the progression of pancreatitis.

THE RISK FACTORS OF ACUTE PANCREATITIS PROGRESSION INTO RECURRENT ACUTE PANCREATITIS AND CHRONIC PANCREATITIS. A SYSTEMATIC REVIEW AND META – ANALYSIS

Endre-Botond Gagyi 1, Mahmoud Obediat 2, Edina Tari 3, Szilárd Váncsa 4, Dániel Sándor Veres 5, Peter Banovcin 6, Peter Jeno Hegyi 4, Peter Hegyi 7, Balint Eross 8

1 Center for Translational Medicine, Semmelweis University, Budapest, Hungary|||Selye János Doctoral College for Advanced Studies, Semmelweis University, Budapest, Hungary

2 Center for Translational Medicine, Semmelweis University, Budapest, Hungary|||Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary

3 Division of Pancreatic Diseases, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary|||Center for Translational Medicine, Semmelweis University, Budapest, Hungary

4 Center for Translational Medicine, Semmelweis University, Budapest, Hungary|||Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary|||Division of Pancreatic Diseases, Heart and Vascular Centre, Semmelweis University, Buda

5 Center for Translational Medicine, Semmelweis University, Budapest, Hungary|||Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary

6 University Hospital in Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia

7 Center for Translational Medicine, Semmelweis University, Budapest, Hungary|||Division of Pancreatic Diseases, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary|||Institute for Translational Medicine, Medical School, University of Pécs,

8 Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary|||Division of Pancreatic Diseases, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary|||Center for Translational Medicine, Semmelweis University, Buda

Conference

UEG Week Copenhagen 2023

Topics

Pancreas

Submission format

Abstract

Session

PP 08 Pancreas (Posters)

Citation

United European Gastroenterology Journal 2023; 11 (Supplement 8)

Published

2023

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Introduction

Pancreatic steatosis (PS) has been increasingly recognized and associated with some relevant metabolic implications. However, data on its correlation with exocrine pancreatic function remain limited. We conducted a systematic review and meta-analysis to evaluate whether PS is associated with exocrine pancreatic insufficiency (EPI).

Aims & Methods

This study aimed to investigate whether imaging-detected PS is related to exocrine pancreatic dysfunction, assessed by fecal elastase-1 (FE-1) levels. We searched PubMed, EMBASE, and Cochrane Central for studies including adults with and without PS identified on imaging, and reporting FE-1 concentrations. Data were pooled using random-effects models.

Results

Three studies evaluating a total of 1,864 patients were included. Fecal elastase levels were significantly lower in patients with PS compared to controls, indicating worse exocrine pancreatic function in this group (MD -199.78; 95% CI -303.66 to -95.91; p < 0.05; I² = 97%). Moreover, PS was associated with a significantly increased risk of exocrine pancreatic insufficiency (RR 3.13; 95% CI 1.17–8.40; p = 0.023; I² = 81%), reinforcing the link between fat accumulation in the pancreas and impaired exocrine function.

Conclusion

This meta-analysis demonstrates a significant association between PS and impaired pancreatic exocrine function, compared to individuals without known pancreas disease. These findings underscore the importance of a comprehensive metabolic assessment in patients with PS, given its potential role in pancreatic dysfunction.

PANCREATIC STEATOSIS AND EXOCRINE PANCREATIC INSUFFICIENCY: A SYSTEMATIC REVIEW AND META-ANALYSIS

Bruna Cerbino 1, Milena Tomé 2

1 Pró-Cardíaco Hospital, 22030040, Brazil

2 Federal University of Campina Grande, Cajazeiras, Brazil

Conference

UEG Week Berlin 2025

Topics

Pancreas

Submission format

Abstract

Session

PANCREAS (Posters)

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

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Introduction

The transition from acute pancreatitis (AP) to recurrent (RAP) and chronic (CP) pancreatitis poses significant clinical challenges.

Aims & Methods

This systematic review and meta-analysis aimed to identify risk factors associated with this progression. Following the protocol registration on PROSPERO (CRD42022368931), we searched Medline, Embase, and Cochrane databases up to December 19th, 2023, for studies examining risk factors for the evolution of AP into RAP or CP. Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using the random effects model. Heterogeneity was evaluated using the I² statistic. The risk of bias assessment was performed using the Quality in Prognostic Studies (QUIPS) tool.

Results

A total of 124 articles were included in the meta–analysis, and several risk factors were identified for the progression of AP into RAP and CP. We found the following risk factors of AP recurrence: male gender, smoking, alcoholic etiology, hypertriglyceridemia, diabetes mellitus, pseudocyst, etc. The pooled OR for the male gender was 1.49 (95% CI: 1.31-1.62, I²=25%), for smoking was 1.47 (95% CI: 1.22-1.71, I²=57%), for alcoholic etiology was 1.78 (95% CI: 1.45-2.14, I²=78%), for hypertriglyceridemia was 2.48 (95% CI: 2.16-2.83, I²=9%), for diabetes mellitus was 1.51 (95% CI: 1.21-1.75, I²=0%), for pseudocyst was 2.23 (95% CI: 1.61-3.12, I²=0%). We also found risk factors of RAP progression into CP. The risk of bias was moderate in the majority of the included studies.

Conclusion

These findings suggest that addressing modifiable risk factors might be key in preventing the progression of pancreatitis

IDENTIFYING PREDICTORS FOR THE EVOLUTION OF ACUTE PANCREATITIS INTO RECURRENT AND CHRONIC FORMS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Endre-Botond Gagyi 1, Mahmoud Obediat 2, Edina Tari 3, Szilárd Váncsa 4, Ádám Zolcsák 2, Peter Banovcin 5, Peter Jeno Hegyi 6, Peter Hegyi 4, Balint Eross 4

1 Centre for Translational Medicine, Semmelweis University, Budapest, Hungary|||Selye János Doctoral College for Advanced Studies, Semmelweis University, Budapest, Hungary

2 Centre for Translational Medicine, Semmelweis University, Budapest, Hungary

3 Semmelweis University, Budapest, Hungary

4 Semmelweis University, Budapest, Hungary|||Centre for Translational Medicine, Semmelweis University, Budapest, Hungary

5 JESSENIUS FACULTY OF MEDICINE, COMENIUS UNIVERSITY, Martin, Slovakia

6 Centre for Translational Medicine, Semmelweis University, Budapest, Hungary|||Semmelweis University, Budapest, Hungary

Conference

UEG Week Vienna 2024

Topics

Pancreas

Submission format

Abstract

Session

PANCREAS (Posters)

Citation

United European Gastroenterology Journal 2024; 12 (Supplement 8)

Published

2024

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