UEG's educational platform for gastroenterology education bringing recordings, courses, guidelines, and more together in one place.

UEG Week Berlin 2025 Recordings Gut Guide online

Rate for better recommendations!

Your feedback helps us show you more of what you like and less of what you dislike!

More of this!

We will show you more similar content.

Not for me!

We won't suggest this again.

Bookmark!

Save this content for later!

New to myUEG? Create an account! Log In with myUEG account

UEG Poster

Standard Poster

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Free for all myUEG account holders. Your access level is set automatically based on your occupation. Medical professionals get full access to all content. If you are a non-medical user, you can only access UEG Week content from congresses you attended.

Not sure what you can access? Learn more about account types.

Introduction

Autoimmune liver diseases (AILDs) includes primary biliary cholangitis (PBC), autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC), in which the immune system produces an inappropriate response to self-antigens leading to chronic liver disease. Gallstone disease is one of the most commonly occurring gastrointestinal disorders. The prevalence of gallbladder stones in patients with chronic liver disease is 22%-54%, higher than the general population¹. Chronic liver disease in most studies mainly refers to viral hepatitis and alcoholic liver disease, and there are no studies on AILDs complicating gallstones. Previous studies have shown that gallstones were associated with autoimmune disease² and were a common cause of secondary sclerosing cholangitis³, but the association between AIH, PBC and gallstones has not been reported yet. We have observed that the combination of AILDs and gallstones are a common phenomenon in clinical practice. Therefore, our study was intended to analyze the proportion and the clinical characteristics of gallstones in patients with AILDs as a reference for clinical decision making in patients with AILDs complicated by gallstones.

Aims & Methods

We investigated the comorbidity of gallstones and risk factors associated with gallstones in patients with AILDs. AILDs patients attending the General Hospital of Tianjin Medical University from November 2012 to October 2022 were retrospectively included. Analysis of the proportion of AILDs patients with gallstones (including patients who underwent cholecystectomy for gallstones), clinical characteristics, and laboratory test. Logistic regression analysis was used to assess the risk factors for the combination of gallstones in patients with AILDs.

Results

A total of 560 patients with AILDs were enrolled, including 207 patients with PBC, 289 with AIH and 64 with PBC-AIH overlap syndrome (PBC-AIH). The proportion of patients with AILDs, PBC, AIH and PBC-AIH complicated by gallstones was 32.50%, 35.75%, 28.37% and 40.63%, respectively. Multiple stones predominate in patients with AILDs complicated by gallstones (43.41%), followed by single stones (32.42%) and sludge (6.04%). Age at first visit (p=0.007) and serum biochemical markers associated with bile duct injury such as GGT (p=0.003) and ALP (p=0.001) were significantly higher in patients with AILDs complicated by gallstones compared to those without gallstones. Age (odd ratio [OR] = 1.024; 95% confidence interval [CI] =1.006-1.042 and serum ALP levels (OR = 1.001; 95% CI = 1-1.002) were independent risk factors for patients with AILDs complicated by gallstones, while serum GGT levels (OR = 1.002; 95% CI = 1-1.003) were independent risk factors for patients with AIH complicated by gallstones. Significantly higher prevalence of gallstones in patients with AILDs older than 61.5 years (p=0.003).

Conclusion

Gallstones are more common comorbidity in AILDs patients, predominantly multiple stones. Age and serum ALP levels were independent risk factors for patients with AILDs complicated by gallstones. Patients with AILDs complicated by gallstones present with significantly elevated serum biochemical parameters associated with bile duct injury. The comorbidity of gallstones tends to delay the initial diagnosis of patients with AILDs.

References

1 Li X, Gao P. Hepatitis C Virus Infection Increases Risk of Gallstone Disease in Elderly Chinese Patients with Chronic Liver Disease. Sci Rep. 2018;8(1):4636. Published 2018 Mar 15. doi:10.1038/s41598-018-22896-4
2 Chapman MH, Thorburn D, Hirschfield GM, et al. British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis. Gut. 2019;68(8):1356-1378. doi:10.1136/gutjnl-2018-317993
3 Shabanzadeh DM, Linneberg A, Skaaby T, Sørensen LT, Jørgensen T. Screen-detected gallstone disease and autoimmune diseases - A cohort study. Dig Liver Dis. 2018;50(6):594-600. doi:10.1016/j.dld.2018.01.12
B4

THE PREVALENCE AND RISK FACTORS FOR GALLSTONES IN AUTOIMMUNE LIVER DISEASES

Yujie Hu 1, Man Liu 1, Lu Zhou 1

1 Tianjin Medical University, Tianjin, China

Conference

UEG Week Copenhagen 2023

Topics

Hepatobiliary

Submission format

Abstract

Session

PP 07 Liver & biliary (Posters)

Citation

United European Gastroenterology Journal 2023; 11 (Supplement 8)

Published

2023

UEG Online Course

New

accredited

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Not sure what you can access? Learn more about account types.

Bowel function is significantly affected after rectal surgery. While sphincter-preserving techniques aim to maintain anal continence, many patients experience a spectrum of bowel dysfunction, collectively known as Low Anterior Resection Syndrome (LARS). LARS includes symptoms such as incontinence, constipation, urgency, and stool clustering, which can severely impact a patient’s quality of life. The prevalence of LARS is alarmingly high, affecting a majority of patients, and symptoms can persist for years after surgical treatment.

Target audience

Gastroenterologists
Colorectal surgeons
Oncologists
Nurses/Stoma therapists
Primary care physicians

Consequences of proctology surgery (LARS)

Harald Rosen, Andreas Rink, Peter Christensen, Franco Marinello

Event

Consequences of proctology surgery (LARS)

Topics

Surgery

Accreditation status

accredited

Duration

1 hour

Published

2026

UEG Online Course

accredited

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Not sure what you can access? Learn more about account types.

This course builds on foundational concepts to examine contemporary mechanisms driving GORD phenotypes. We revisit key epidemiological and clinical distinctions before exploring gastric physiology, including postprandial acid–bile dynamics, H. pylori-related acid output, motility patterns, obesity-related changes, and post-surgical anatomy. Oesophagogastric junction competence (LES pressure, TLESRs, hiatal hernia) and refluxate characteristics (acidic to gaseous; PPI-modified) are discussed with emphasis on symptom generation. We detail epithelial biology, micro- and macroinflammatory responses across NERD and erosive disease, and advances in nociceptive signalling, receptor expression, central modulation, and hypervigilance. Key clinical studies, cytokine-driven pathways, and emerging therapeutic approaches are highlighted. The course concludes with implications for diagnosis, phenotype-guided management, and outstanding research questions.

GORD Pathophysiology - Part 2

Edoardo Savarino, Ahsen Ustaoglu

Event

GORD Pathophysiology Part 2

Topics

Neurogastroenterology & Motility

Accreditation status

accredited

Duration

1 hour

Published

2026

UEG Online Course

accredited

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Not sure what you can access? Learn more about account types.

Modern guideline development has evolved over the last 20 years to improve quality of clinical guidelines.

This course aims to provide basic knowledge of developing guidelines. It will explain the process of how to go about writing protocol, the very basics regarding GRADE, and what you need to do after completing a guideline. It will also signpost you to other courses organised by Guideline International Network.

The course includes comprehensive PPT slides and bespoke video presentations. The combined material has a total duration of approximately 30 minutes. The estimated time needed to complete the course, including the final assessment, is 45 minutes.

Target audience

This course is suitable for gastroenterologists in training, but is also appropriate for physicians in other disciplines and surgeons , as well as nurses, biotechnicians and advanced-years’ medical students who have an interest in developing guidelines.

Enrol Part 2: How to develop guidelines - Part 2

How to develop guidelines - Part 1

Yasuko Maeda, Adele Sayers, Ana Dugic

Event

How to develop guidelines - Part 1

Topics

Education & Training

Accreditation status

accredited

Duration

45 minutes

Published

2024

UEG Online Course

accredited

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Not sure what you can access? Learn more about account types.

Building on the foundations covered in Part 1, this second course provides a deeper dive into the essential steps of guideline development. Participants will learn how to identify when a new guideline or statement is warranted, formulate focused clinical questions using PICO, and translate these into comprehensive search strategies. The course also covers the application of GRADE domains to assess evidence certainty, and guides learners through the Evidence-to-Decision framework. Finally, it clarifies the difference between good practice statements and formal guideline recommendations, ensuring participants gain the practical skills needed to contribute effectively to high-quality guideline development.

Target Audience:

Healthcare professionals interested in developing guidelines
Patients and stakeholders interested in understanding the process of guideline development

How to develop guidelines - Part 2

Yasuko Maeda, Adele Sayers

Event

How to develop guidelines - Part 2

Topics

Primary Care Education & Training

Accreditation status

accredited

Duration

1 hour

Published

2025

UEG Standards and Guidelines

Clinical Practice Guideline

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Not sure what you can access? Learn more about account types.

Main Recommendations

1 ESGE recommends that the initial assessment of patients presenting with acute lower gastrointestinal bleeding should include: a history of co-morbidities and medications that promote bleeding; hemodynamic parameters; physical examination (including digital rectal examination); and laboratory markers. A risk score can be used to aid, but should not replace, clinician judgment.

Strong recommendation, low quality evidence.

2 ESGE recommends that, in patients presenting with a self-limited bleed and no adverse clinical features, an Oakland score of <= 8 points can be used to guide the clinician decision to discharge the patient for outpatient investigation.

Strong recommendation, moderate quality evidence.

3 ESGE recommends, in hemodynamically stable patients with acute lower gastrointestinal bleeding and no history of cardiovascular disease, a restrictive red blood cell transfusion strategy, with a hemoglobin threshold of <= 7 g/dL prompting red blood cell transfusion. A post-transfusion target hemoglobin concentration of 7–9 g/dL is desirable.
Strong recommendation, low quality evidence.

4 ESGE recommends, in hemodynamically stable patients with acute lower gastrointestinal bleeding and a history of acute or chronic cardiovascular disease, a more liberal red blood cell transfusion strategy, with a hemoglobin threshold of <= 8 g/dL prompting red blood cell transfusion. A post-transfusion target hemoglobin concentration of >= 10 g/dL is desirable.

Strong recommendation, low quality evidence.

5 ESGE recommends that, in patients with major acute lower gastrointestinal bleeding, colonoscopy should be performed sometime during their hospital stay because there is no high quality evidence that early colonoscopy influences patient outcomes.

Strong recommendation, low quality of evidence.

6 ESGE recommends that patients with hemodynamic instability and suspected ongoing bleeding undergo computed tomography angiography before endoscopic or radiologic treatment to locate the site of bleeding.

Strong recommendation, low quality evidence.

7 ESGE recommends withholding vitamin K antagonists in patients with major lower gastrointestinal bleeding and correcting their coagulopathy according to the severity of bleeding and their thrombotic risk. In patients with hemodynamic instability, we recommend administering intravenous vitamin K and four-factor prothrombin complex concentrate (PCC), or fresh frozen plasma if PCC is not available.

Strong recommendation, low quality evidence.

8 ESGE recommends temporarily withholding direct oral anticoagulants at presentation in patients with major lower gastrointestinal bleeding.

Strong recommendation, low quality evidence.

9 ESGE does not recommend withholding aspirin in patients taking low dose aspirin for secondary cardiovascular prevention. If withheld, low dose aspirin should be resumed, preferably within 5 days or even earlier if hemostasis is achieved or there is no further evidence of bleeding.

Strong recommendation, moderate quality evidence.

10 ESGE does not recommend routinely discontinuing dual antiplatelet therapy (low dose aspirin and a P2Y12 receptor antagonist) before cardiology consultation. Continuation of the aspirin is recommended, whereas the P2Y12 receptor antagonist can be continued or temporarily interrupted according to the severity of bleeding and the ischemic risk. If interrupted, the P2Y12 receptor antagonist should be restarted within 5 days, if still indicated.

Strong recommendation, low quality evidence.

Diagnosis and management of acute lower gastrointestinal bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Konstantinos Triantafyllou

Publisher

European Society of Gastrointestinal Endoscopy

Guideline

Clinical Practice Guideline

Topics

Endoscopy

Citation

Endoscopy 2021; 53(08): 850-868

Published

2021

UEG Online Course

accredited

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Not sure what you can access? Learn more about account types.

This comprehensive course introduces participants to the transformative role of artificial intelligence in gastroenterology. Designed for healthcare professionals, the course covers fundamental AI concepts, clinical applications, and research perspectives. Key topics include machine learning techniques, AI-assisted diagnostics, and the integration of AI systems in clinical practice. Participants will explore the benefits and challenges of AI adoption, ethical considerations, and the regulatory landscape, with an emphasis on evidence-based decision-making.

The course includes extensive PowerPoint presentations and tailored video lectures. Examples are used to demonstrate real-world applications of the material. The total duration of the course is approximately 50 minutes, with an estimated completion time of 60 minutes, including the final assessment.

A Primer for Artificial Intelligence in Gastroenterology

Cem Simsek, Giulio Antonelli, Alanna Ebigbo

Event

A Primer for Artificial Intelligence in Gastroenterology

Topics

Endoscopy

Accreditation status

accredited

Duration

1 hour

Published

2025

UEG's educational platform for gastroenterology education bringing recordings, courses, guidelines, and more together in one place.

Most popular content

Rate for better recommendations!