Mistakes in gastro-oesophageal reflux disease diagnosis and how to avoid them

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Mistakes in gastro-oesophageal reflux disease diagnosis and how to avoid them

Francois Mion, Sabine Roman

Summary

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Gastro-oesophageal reflux disease is a frequently encountered condition affecting quality of life, defined by troublesome symptoms or complications from stomach content reflux, with an estimated prevalence of around 24% in Europe.

According to the Montreal definition, GORD develops when reflux of stomach contents causes troublesome symptoms and/or complications.
Heartburn and regurgitation are typical symptoms of GORD, while chest pain, cough and sore throat are considered atypical symptoms, though none is pathognomonic.
GORD has an estimated prevalence of around 24% in Europe and accounts for $9 billion per year in healthcare costs in the US.
GORD has a negative effect on quality of life and is frequently encountered in clinical practice.

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Abstract

According to the Montreal definition, “[gastro-oesophageal reflux disease (GORD)] is a condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications.”1 GORD has a negative effect on quality of life and is frequently encountered in clinical practice, with an estimated prevalence of around 24% in Europe. In the US, GORD-related healthcare costs account for $9 billion per year. A variety of symptoms are associated with GORD—heartburn and regurgitation are typical symptoms, while chest pain, cough and sore throat are considered atypical symptoms—but none is pathognomonic

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Neurogastroenterology & Motility Oesophagus

Citation

Roman S and Mion F. Mistakes in gastro-oesophageal reflux disease and how to avoid them. UEG Education 2017; 17: 24–26.

Published

2024

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UEG Mistakes In Articles

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Mistakes in rumination syndrome and how to avoid them

Alberto Ezquerra-Durán, Elizabeth Barba Orozco

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Abstract

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Neurogastroenterology & Motility

Citation

Ezquerra-Durán A and Barba-Orozco E. Mistakes in rumination syndrome and how to avoid them. UEG Education 2025; 25: 10-13.

Published

2025

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UEG Podcast Episode

UEG Podcast

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MASLD with Sven Francque - Part 2

Sven Francque, Pradeep Mundre

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Abstract

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Hepatobiliary

Published

2026

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UEG Mistakes In Articles

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Mistakes in the use of PPIs and how to avoid them

Albert J. Bredenoord, Roos E. Pouw

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Abstract

Proton pump inhibitors (PPIs), first introduced with omeprazole in 1988, revolutionized the treatment of gastric acid-related conditions like gastro-oesophageal reflux disease, gastroduodenal ulcers, and Helicobacter pylori infections. Despite their effectiveness, PPIs are often prescribed for conditions without a proven link to gastric acid, such as dyspepsia and upper abdominal discomfort. Long-term use of PPIs has raised safety concerns, including risks of vitamin and mineral malabsorption, pneumonia, gastrointestinal infections, and dementia. This Mistakes In article addresses nine common mistakes in PPI use and aims to clarify misconceptions about their use.

Topics

Digestive Oncology Oesophagus

Citation

Pouw R.E. and Bredenoord A.J. Mistakes in the use of PPIs and how to avoid them. UEG Education 2017; 17: 15–17.

Published

2024

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UEG Mistakes In Articles

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

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Mistakes in the management of unexplained diarrhoea and how to avoid them

Magnus Simrén, Hans Törnblom

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Abstract

Diarrhoea, acute or chronic, is a common gastrointestinal symptom in healthcare. In most cases, acute diarrhoea in healthy individuals requires limited diagnostic and therapeutic efforts, except for the replacement of fluid electrolytes, and stool culture in severe occurrences. Acute diarrhoea is often self-limiting due to short-lived reactions to food intake and bacterial or viral infections. However, diarrhoea can persist and fulfil definitions of chronicity when a month or more has passed since the onset. Here we discuss some basic mistakes that should be avoided when managing unexplained non-bloody diarrhoea that persists beyond the acute setting. In this context, the term 'unexplained' refers to a patient without apparent alarm features and where initial consultations have failed at making a diagnosis. We used an evidence-based approach and included aspects predominantly based on clinical experience when appropriate.

Topics

Neurogastroenterology & Motility

Citation

Törnblom H and Simrén M. Mistakes in the management of unexplained diarrhoea and how to avoid them. UEG Education 2022; 22: 16–19.

Published

2022

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UEG Mistakes In Articles

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

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Mistakes in paediatric inflammatory bowel disease and how to avoid them

Neil Chanchlani, Richard K Russell

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Abstract

Around 1 in 10 cases of inflammatory bowel disease (IBD) will present before adulthood, with the median age at presentation being 11–12 years. IBD in children and young people is associated with more extensive disease, increased disease activity and a higher rate of complications compared with adult-onset IBD. Worldwide, estimates of paediatric IBD prevalence rates are lacking, but data suggest its incidence is increasing.

Topics

IBD Paediatrics

Citation

Chanchlani N. and Russell R.K. Mistakes in paediatric inflammatory bowel disease and how to avoid them. UEG Education 2018; 18: 1–6.

Published

2018

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Mistakes in rumination syndrome and how to avoid them

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Mistakes in the use of PPIs and how to avoid them

Albert J. Bredenoord

Mistakes in the management of unexplained diarrhoea and how to avoid them

Magnus Simrén

Mistakes in paediatric inflammatory bowel disease and how to avoid them

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Mistakes in clinical investigation of gastrointestinal motility and function

Mark Fox

UEG Mistakes In Articles

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

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Mistakes in clinical investigation of gastrointestinal motility and function

Mark Fox

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Abstract

A recent UEG survey indicated that dysphagia, heartburn, bloating, abdominal pain and changes to bowel habit are each reported by 5–15% of the general population.1 For patients with mild symptoms, negative tests provide reassurance and simple, symptomatic management might be all that is required (e.g. acid suppression, stool regulation). However, for those with severe symptoms that persist on therapy, ruling out life-threatening disease is not sufficient, and referral to the neurogastroenterology and motility (NGM) laboratory for physiological measurements is often indicated. Clinical investigations aim to explain the cause of symptoms and establish a diagnosis that can guide rational treatment. Until recently, it could be argued that manometry, scintigraphy, breath tests and related tests rarely provided this information. As a result, only patients with suspected major motility disorders (e.g. achalasia, severe reflux disease or faecal incontinence) were routinely referred to the NGM laboratory for tests. Technological advances, such as high-resolution manometry (HRM), now provide objective measurements not only of motility, but also of function in terms of the movement (and digestion) of ingested material within the gastrointestinal tract. Furthermore, the ability to associate events (such as bolus retention, reflux or gas production) with symptoms provides an indication of visceral sensitivity and can identify what is causing patient complaints. Here, I discuss frequent mistakes in clinical investigation of gastrointestinal motility and function based on a series of consensus documents published by members of the International Working Group for Disorders of Gastrointestinal Motility and Function.

Topics

Neurogastroenterology & Motility

Citation

Fox M. Mistakes in clinical investigation of gastrointestinal motility and function. UEG Education 2018; 18: 15–20.

Published

2024

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