Introduction
Helicobacter pylori (HP) is regarded as a class I carcinogenic factor and eradication therapy can reduce the risk of gastric cancer. Patients with HP infections are administered with bismuth quadruple therapy (BQT), triple and dual therapies based on their eradication effectiveness. BQT (bismuth + acid suppressants + 2 antibiotics) and dual therapy are both recommended in China now. Comprehensive understanding on the distribution of current eradication therapies is required to identify gaps observed in real-world practice.
Aims & Methods
This multicenter, retrospective, real-world study (NCT05073367) extracted preexisting electronic data including adult patients (aged ≥18 years) with HP infection between January 1, 2019 and March 31, 2021 from 3 hospitals to assess the diagnosis and treatment pattern of HP infection and effectiveness of eradication therapy in China. In this abstract, we reported the distribution of eradication therapies, difference in initiation year for treatment, and treatment duration.
Results
Of the 22,971 eligible patients with HP infection, 13,233 (57.61%) were prescribed eradication regimens. Mean ± SD age of patients with eradication treatment was 43.7 ± 14.0 years; 65.94% of patients had medical insurance; and 54.50% of patients were women.
In patients who received eradication therapy, the BQT therapy was predominantly prescribed (85.39%; n=11301), followed by triple therapy (7.55%; n=999) and dual therapy (7.06%; n=934). Among those receiving BQT, use of amoxicillin + clarithromycin based regimens (38.72%; n=4376) were the most prevalent, followed by amoxicillin +furazolidone (18.35%; n=2074) and amoxicillin + levofloxacin (17.76%; n=2007) based combination regimens. Proportion of patients receiving BQT decreased over years: 97.24% patients in 2019, 79.98% in 2020, and 78.71% in 2021. The proportion of patients receiving dual and triple therapy increased over the years in 2019, 2020, and 2021 were shown in Table 1. A total of 10,903 patients were analyzed according to various treatment durations with the usage of various eradication therapies. Treatment duration is defined as the number of days that prescribed drugs can cover. Out of the three types of treatments, BQT had the highest proportion of 14-day treatment duration at 90.16%, followed by triple therapy at 76.78%, while dual therapy had the least proportion at 14.42%. For treatment duration >14 days, BQT, dual and triple therapy had a proportion of 4.38%, 82.35%, and 17.27% respectively.
Table 1. Distribution of eradication therapy based upon the type and year of treatment initiation
| Treatment | Type of Eradication therapy
(N=13, 234)
n (%)a | Year of treatment initially prescribed , 2019
(N=4492)
n (%)a | Year of treatment initially prescribed, 2020
(N=4125)
n (%)a | Year of treatment initially prescribed, 2021
(N=4616)
n (%)a |
Total
Bismuth quadruple therapy
Amoxicillin and Clarithromycin
Amoxicillin and Furazolidone
Amoxicillin and Levofloxacin
Amoxicillin and Metronidazole
Amoxicillin and Tetracycline
Furazolidone and Tetracycline
Other Bismuth quadruple
Triple therapyc
Dual therapyc | 13,234b (-)
11,301 (85.39)
4376 (38.72)
2074 (18.35)
2007 (17.76)
76 (0.67)
9 (0.08)
12 (0.11)
2747 (24.31)
999 (7.55)
934 (7.06) | 4492 (-)
4368 (97.24)
1800 (41.21)
689 (15.77)
1021 (23.37)
27 (0.62)
5 (0.11)
1 (0.02)
825 (18.89)
105 (2.34)
19 (0.42) | 4125 (-)
3299 (79.98)
1324 (40.13)
480 (14.55)
516 (15.64)
10 (0.30)
1 (0.03)
0 (0.00)
968 (29.34)
551 (13.36)
275 (6.67) | 4617 (-)
3634 (78.71)
1252 (34.45)
905 (24.90)
470 (12.93)
39 (1.07))
3 (0.08)
11 (0.30)
954 (26.25)
343 (7.43)
640 (13.86) |
Abbreviations: N, total number; n, number in respective category.
a% = The total usage count of BQT or Triple or Dual eradication therapy/the total usage count of all standard eradication therapies received by eligible participants. Of BQT, the total usage count of different BQT/the total usage count of all BQT.
bThere is a recurrent patient who changed the treatment pattern from triple therapy (ilaprazole, clarithromycin, levofloxacin) to dual therapy (ilaprazole, ornidazole) after the recurrence.
cConsidering the table size, outcomes of different treatment regimens under dual and triple therapy were not included in the table.
Conclusion
BQT-based regimen for 14 days was the predominant eradication regimens in all therapies, amoxicillin + clarithromycin based BQT was the most prevalent. Use of dual therapy gradually increased with years for HP eradication in the Chinese real-world clinical practice.
Disclosure
The study was funded by Takeda China. Wensheng Pan, Yan Zhao, and Hongwei Xu have no conflicts of interest. Pengfei Li, Fang Zhou, Li Xie are the employees of Takeda, and they hold Takeda stock options. Medical writing for the development of this abstract was provided by Kusuma Kumari G, PhD, of Indegene Private Limited, and funded by Takeda China. Authors retained full control of the abstract content.