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UEG Research Prize 2024: The WATERLAND study

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UEG Research Prize 2024: The WATERLAND study

Silvio Danese 1, Enrique de-Madaria 2

Affiliations

1 Vita-Salute San Raffaele University - IRCCS San Raffaele Scientific Institute, Milan, Italy

2 Hospital General Universitario de Alicante - Gastroenterology, Hospital General Universitario de Ali, Alicante, Spain

Summary

AI Generated

The speaker presented the Waterfall and Waterland trials investigating fluid resuscitation strategies in acute pancreatitis, reporting that the Waterfall trial was stopped early when aggressive fluid resuscitation showed increased fluid overload risk without improved outcomes.

The Waterfall trial, an international randomised trial across 18 centres in 4 countries, was stopped at interim analysis for safety reasons after aggressive fluid resuscitation was associated with increased fluid overload and no improvement in outcomes compared to moderate resuscitation, as stated by the speaker.
The speaker reported that the American College of Gastroenterology guidelines now recommend moderately aggressive fluid resuscitation in acute pancreatitis based on the Waterfall trial findings.
An earlier 40-patient trial comparing lactated Ringer's to normal saline showed lower C-reactive protein levels at 2-3 days with lactated Ringer's, though guidelines noted this was not a hard patient outcome.
The ongoing Waterland trial is randomising almost 800 patients across 47 centres in 18 countries to lactated Ringer's versus normal saline for at least 48 hours, with severity as the primary outcome; the speaker stated results are pending and this will be the largest acute pancreatitis trial by patient and country count.
The speaker disclosed receiving the UEG Research Prize 2021 and previous UEG Rising Star and Ambassador Awards for this fluid resuscitation research program spanning approximately 15 years.

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Abstract

Event

UEG Week Vienna 2024

Session

Opening Plenary

Citation

United European Gastroenterology Journal 2024; 12 (Supplement 8)

Published

2024

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IBD in pregnancy with Mette Julsgaard - Part 1

Mette Julsgaard, Pradeep Mundre

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Abstract

Topics

IBD

Published

2026

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Patrizia Burra, Jorge Amil Dias, Pradeep Mundre

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Abstract

Topics

Paediatrics

Published

2025

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Best practises for caring for LGBTQ+ people in GI with Alexander Goldowsky

Egle Dieninyte - Misiune, Charles Murray

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Abstract

Published

2025

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Mistakes in pancreatic cystic neoplasms and how to avoid them

Marco Del Chiaro, Juan Enrique Dominguez-Munoz, Giovanni Marchegiani

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Abstract

Pancreatic cystic neoplasms (PCN) are a frequent and clinically challenging condition. PCN prevalence increases with age and reports estimate that they may be present in 2–45% of the general population. In addition, the biological behaviour of the various types of PCN differs (ranging from benign to malignant [table 1]), requiring different surveillance and therapeutic approaches. Correct management of PCN is, therefore, critical for avoiding progression to cancer, but at the same time avoiding unneeded close and long-term follow-up, unnecessary invasive diagnostic procedures and overtreatment.

Topics

Digestive Oncology Pancreas

Citation

Domínguez-Muñoz J.E. and Del Chiaro M. Mistakes in pancreatic cystic neoplasms and how to avoid them. UEG Education 2018; 18: 35–37.

Published

2024

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Pathogenesis, Classification, and Differential Diagnosis

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Pathogenesis, Classification, and Differential Diagnosis

Juozas Kupcinskas 1

Affiliations

1 Lithuanian University of Health Sciences, Kaunas, Lithuania

Summary

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Abstract

Event

Postgraduate Teaching Programme Barcelona 2026

Topics

Surgery Endoscopy Colorectal

Session

What’s new in diverticular disease of the colon

Citation

2026: United European Gastroenterology Journal 2026; 14 (S1)

Published

2026

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Not sure what you can access? Learn more about account types.

PSC-IBD crosstalk: From mechanisms to meaningful clinical practice (Dr. Falk Pharma) (Complete Session)

Münevver Demir 1, Michael Trauner 2, Emma Culver 3, Palak Trivedi 4

Affiliations

1 Charité - Universitätsmedizin, Berlin, Germany

2 Medical University of Vienna, Vienna, Austria

3 John Radcliffe Hospital, Oxford, Oxford, United Kingdom

4 University of Birmingham, Birmingham, United Kingdom

Summary

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Abstract

Publisher

Dr. Falk Pharma GmbH

Event

UEG Week Barcelona 2026

Session

PSC-IBD crosstalk: From mechanisms to meaningful clinical practice (Dr. Falk Pharma)

Citation

2026: United European Gastroenterology Journal 2026; 14 (S1)

Published

2026

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