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UEG Research Prize 2024: The WATERLAND study

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UEG Research Prize 2024: The WATERLAND study

Silvio Danese 1, Enrique de-Madaria 2

Affiliations

1 Vita-Salute San Raffaele University - IRCCS San Raffaele Scientific Institute, Milan, Italy

2 Hospital General Universitario de Alicante - Gastroenterology, Hospital General Universitario de Ali, Alicante, Spain

Summary

AI Generated

The speaker presented the Waterfall and Waterland trials investigating fluid resuscitation strategies in acute pancreatitis, reporting that the Waterfall trial was stopped early when aggressive fluid resuscitation showed increased fluid overload risk without improved outcomes.

The Waterfall trial, an international randomised trial across 18 centres in 4 countries, was stopped at interim analysis for safety reasons after aggressive fluid resuscitation was associated with increased fluid overload and no improvement in outcomes compared to moderate resuscitation, as stated by the speaker.
The speaker reported that the American College of Gastroenterology guidelines now recommend moderately aggressive fluid resuscitation in acute pancreatitis based on the Waterfall trial findings.
An earlier 40-patient trial comparing lactated Ringer's to normal saline showed lower C-reactive protein levels at 2-3 days with lactated Ringer's, though guidelines noted this was not a hard patient outcome.
The ongoing Waterland trial is randomising almost 800 patients across 47 centres in 18 countries to lactated Ringer's versus normal saline for at least 48 hours, with severity as the primary outcome; the speaker stated results are pending and this will be the largest acute pancreatitis trial by patient and country count.
The speaker disclosed receiving the UEG Research Prize 2021 and previous UEG Rising Star and Ambassador Awards for this fluid resuscitation research program spanning approximately 15 years.

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This summary was generated by an AI large language model based on the content transcript. It is for informational purposes only and should not be considered a substitute for clinical judgment. Always rely on your professional expertise and the full clinical context when making clinical decisions.

Abstract

Event

UEG Week Vienna 2024

Session

Opening Plenary

Citation

United European Gastroenterology Journal 2024; 12 (Supplement 8)

Published

2024

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