UEG's content platform for gastroenterology education bringing recordings, courses, guidelines, and more together in one place.

Re-live UEG Week 2026 on Gutflix Gut Guide online What's new on Gutflix

Trending on Gutflix

Rate for better recommendations!

Your feedback helps us show you more of what you like and less of what you dislike!

More of this!

We will show you more similar content.

Not for me!

We won't suggest this again.

Bookmark!

Save this content for later!

New to myUEG? Create an account! Log In with myUEG account

UEG Poster

Standard Poster

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

ARTIFICIAL INTELLIGENCE IN THE DIFFERENTIAL DIAGNOSIS OF INFLAMMATORY BOWEL DISEASES AND IRRITABLE BOWEL SYNDROME

Igor Bakulin 1, Irina Rasmagina 1, Olga Konstantinova 1, Konstantin Shpilkin 1, Gleb Mashevskiy 2

Affiliations

1 North-Western State Medical University n.a. I.I.Mechnikov, Saint-Petersburg, Russian Federation

2 Saint Petersburg Electrotechnical University "LETI", Saint-Petersburg, Russian Federation

Summary

AI Generated

A retrospective study of 1006 patients developed artificial neural networks to distinguish inflammatory bowel disease from irritable bowel syndrome using clinical and laboratory markers, achieving high sensitivity (95.8%) and specificity (90.2%) for IBD detection but only moderate accuracy (75-79%) for differentiating Crohn's disease from ulcerative colitis.

The multilayer perceptron ANN achieved 95.8% sensitivity and 90.2% specificity in distinguishing IBD from IBS using clinical symptoms, anamnesis data, and laboratory tests including fecal calprotectin
Key IBD distinguishing features included diarrhea 5 or more times daily (40.0% vs 6.2% in IBS), blood in stool (65.3% vs 6.8%), higher fecal calprotectin, and presence of extraintestinal or perianal manifestations
IBS patients were significantly more likely to have constipation (34.8% vs 5.0%), fewer bowel movements, and absence of extraintestinal manifestations (94.1% vs 66.3%)
A linear ANN with 5 input neurons showed moderate accuracy in differentiating UC from CD (78.7% for CD detection, 75.4% for UC), with perianal manifestations and prior intestinal surgery more common in CD
The authors conclude further work is required to improve accuracy and enable clinical implementation of these diagnostic tools

Download PDF

Was this helpful?

Thanks for your feedback.

This summary was generated by an AI large language model based on the content transcript. It is for informational purposes only and should not be considered a substitute for clinical judgment. Always rely on your professional expertise and the full clinical context when making clinical decisions.

Abstract

Introduction

A differential diagnosis of inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS) is one of the unresolved problems in modern gastroenterology. The absence of clear criteria for IBD detection leads to delay in the diagnostic process for months and years.

Aims & Methods

The aim of the study was to identify clinical and laboratory markers that could distinguish between IBD and IBS with a subsequent development of an artificial neural network (ANN).
We retrospectively evaluated the clinical symptoms, anamnesis data and laboratory tests of patients with verified exacerbation of Crohn`s disease (CD) and ulcerative colitis (UC), and IBS. We found parameters that could distinguish IBD and IBS and then CD and UC, and used them to create the ANN.

Results

Of the 1006 examined, 32% were patients with IBS and 68% with IBD. Patients with IBS were significantly more likely to have a tendency to constipation (34.8% compared with 5.0% in IBD patients), loose stool up to 2 times (26.9% compared with 17.0%), the absence of extraintestinal (EIMs) (94.1% compared to 66.3%) and perianal manifestations (PAM) (96.0% compared to 83.5%) (p<0.001). The patients with IBD had diarrheal syndrome ≥ 5 times a day more frequently (40.0% and 6.2% in patients with IBS, respectively), blood admixture (65.3% and 6.8%, respectively) and higher level of fecal calprotectin (p<0.001). All these data were used to create and train the ANN on general and test (15% of all cases) dataset. Multilayer perceptron showed the best results in IBD detection: the sensitivity was 95.8% and the specificity was 90.2%.
To create the ANN for IBD differentiation, we analyzed medical histories of 350 patients (51%) with UC and 333 (49%) with CD. Statistical analysis in the group with UC significantly more often had severe diarrheal syndrome (≥ 5 times a day) (48.3% compared to 42.3% among the patients with CD), blood in the stool (87.1% compared to 79.0%, respectively), the absence of EIMs (73,4% compared to 58,9%, respectively) and PAMs (97,4% compared to 58,9%, respectively) (p<0,001). Patients with CD compared with UC were significantly more likely to have constipation (7.2% compared to 2.9%, respectively) (p=0.002), increased stool up to 2 times (21,6% compared to 12,6%, respectively), subfebrile temperature (25.8% compared to 16.9%, respectively) (p=0.004) and surgical intervention on the small and large intestines in the anamnesis (20.1% in compared to 1.4%, respectively) (p<0.001). The clinical and anamnestic parameters identified in our study were used to create and train the ANN. The best results were shown by a linear set with 5 input neurons: the accuracy of detecting CD was 78.7% and UC - 75.4%, which shows a moderate ability of the ANN to differentiate UC and CD.

Conclusion

As a result of the study, we created the ANNs with high sensitivity and specificity in the differentiation of organic and functional intestinal diseases and with moderate accuracy in IBD differentiation. The developed ANN can help clinicians in the diagnosis of IBD and IBS, but further work for improving its accuracy and the possibility of implementation into clinical practice is required.

Disclosure

All authors have declared no conflict of interest.

Conference

UEG Week Copenhagen 2023

Topics

IBD

Submission format

Abstract

Session

PP 05 IBD (Posters)

Citation

United European Gastroenterology Journal 2023; 11 (Supplement 8)

Published

2023

More Like This:

The role of endoscopy in diagnosis and monitoring of IBD: Present and future directions

Marietta Iacucci

THE MEDITERRANEAN DIET FOR IRRITABLE BOWEL SYNDROME

Rachel Buckle

Constipation: Paediatric and adult gastroenterologist

Maura Corsetti

UEG Week+ | Burnout in European Gastroenterology - A call to action

Martina Müller-Schilling

IBD

Matthew Ciorba

Nutrition: Getting the best out for the patient!

Christian Lodberg Hvas

UEG Presentation

New

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

The role of endoscopy in diagnosis and monitoring of IBD: Present and future directions

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

The role of endoscopy in diagnosis and monitoring of IBD: Present and future directions

Marietta Iacucci 1

Affiliations

1 University College Cork, Cork, Ireland

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Event

Postgraduate Teaching Programme Barcelona 2026

Topics

IBD

Session

Monitoring of disease activity in IBD

Citation

2026: United European Gastroenterology Journal 2026; 14 (S1)

Published

2026

More Like This:

The role of endoscopy in diagnosis and monitoring of IBD: Present and future directions

Marietta Iacucci

THE MEDITERRANEAN DIET FOR IRRITABLE BOWEL SYNDROME

Rachel Buckle

Constipation: Paediatric and adult gastroenterologist

Maura Corsetti

UEG Week+ | Burnout in European Gastroenterology - A call to action

Martina Müller-Schilling

IBD

Matthew Ciorba

Nutrition: Getting the best out for the patient!

Christian Lodberg Hvas

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

THE MEDITERRANEAN DIET FOR IRRITABLE BOWEL SYNDROME

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

THE MEDITERRANEAN DIET FOR IRRITABLE BOWEL SYNDROME

Joy Bamidele 1, Grace Brownlow 1, Rosie Flack 1, Rachel Buckle 2, Christian Shaw 2, Mo Shiha 1, Imran Aziz 1

Affiliations

1 University of Sheffield, Sheffield, United Kingdom

2 Sheffield Teaching Hospitals, Sheffield, United Kingdom

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Introduction

Patients with irritable bowel syndrome (IBS) frequently seek dietary advice. However, few evidence-based options exist. Societal guidelines recommend traditional dietary advice (TDA) as first-line therapy, with the cumbersome and resource-intensive low FODMAP diet reserved as second-line therapy.
Recent pilot data suggests that the Mediterranean diet (MD), renowned for its general health benefits, improves the symptoms of IBS. Whether it can be considered another first-line dietary option is not known.

Aims & Methods

This randomized non-inferiority clinical trial assigned 139 individuals with IBS, from across the United Kingdom, to follow the MD (n=68) or TDA (n=71) for six weeks. The primary endpoint was the proportion of participants achieving clinical response, defined as a ≥50-point reduction in the IBS Symptom Severity Scale (IBS-SSS). Secondary outcomes included changes in IBS-SSS, psychological health, somatic symptom reporting, quality of life, diet satisfaction, and the Mediterranean Diet Adherence Screener (MEDAS).

Results

Baseline characteristics (mean age 40.4 [range 19-65] years, 80% female) and IBS-SSS (mean 309, SD 90) were similar between groups. On modified intention-to-treat analysis, the primary endpoint was met by 62% (95% CI 50%-73%) taking a MD versus 42% (95% CI 31%-55%) taking TDA. The difference in clinical response between the groups was in favor of the MD (20%, 95% CI 4%-36%), demonstrating it to be non-inferior based on the a priori defined requirement for the CI to exclude -5%. Rather, the MD was superior to TDA (odds ratio 2.3 [95% CI: 1.16-4.64], p = 0.017). There was a greater reduction in the mean IBS-SSS following a MD than TDA (-101.2 vs. -64.5, ∆-36.7 [95% C.I. -70.5 to -2.8], p=0.034). No significant differences were observed between the groups with regards to changes in mood, somatic symptoms, quality of life or diet satisfaction. The MEDAS significantly increased following a MD compared with TDA (p< 0.001).

Conclusion

The MD is non-inferior (rather, it demonstrated superiority) to TDA in managing the symptoms of IBS, and can be considered as another first-line dietary option.
Clinical trials registration: NCT05985018

Disclosure

Nil

Event

UEG Week Berlin 2025

Topics

Gut Microbiota Neurogastroenterology & Motility Small Intestine & Nutrition Colorectal

Submission format

Abstract

Session

Lower GI motility II

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

The role of endoscopy in diagnosis and monitoring of IBD: Present and future directions

Marietta Iacucci

THE MEDITERRANEAN DIET FOR IRRITABLE BOWEL SYNDROME

Rachel Buckle

Constipation: Paediatric and adult gastroenterologist

Maura Corsetti

UEG Week+ | Burnout in European Gastroenterology - A call to action

Martina Müller-Schilling

IBD

Matthew Ciorba

Nutrition: Getting the best out for the patient!

Christian Lodberg Hvas

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Constipation: Paediatric and adult gastroenterologist

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

Constipation: Paediatric and adult gastroenterologist

Marc Benninga 1, Maura Corsetti 2

Affiliations

1 Academisch Medisch Centrum Onderzoekschool Oncologie Pediatrics and Pediat. Surgery - Dep. Of Pediat, AZ Amsterdam, Netherlands

2 University of Nottingham, Nottingham, United Kingdom

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Event

UEG Week Berlin 2025

Session

When adult gastroenterologist meets paediatrician: Focus on reflux, constipation and chronic pain

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

The role of endoscopy in diagnosis and monitoring of IBD: Present and future directions

Marietta Iacucci

THE MEDITERRANEAN DIET FOR IRRITABLE BOWEL SYNDROME

Rachel Buckle

Constipation: Paediatric and adult gastroenterologist

Maura Corsetti

UEG Week+ | Burnout in European Gastroenterology - A call to action

Martina Müller-Schilling

IBD

Matthew Ciorba

Nutrition: Getting the best out for the patient!

Christian Lodberg Hvas

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

UEG Week+ | Burnout in European Gastroenterology - A call to action

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

UEG Week+ | Burnout in European Gastroenterology - A call to action

Iago Rodríguez-Lago, Reena Sidhu, Martina Müller-Schilling

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Event

UEG Week Copenhagen 2023

Session

UEG Week+ | Burnout in European Gastroenterology - A call to action

Published

2023

More Like This:

The role of endoscopy in diagnosis and monitoring of IBD: Present and future directions

Marietta Iacucci

THE MEDITERRANEAN DIET FOR IRRITABLE BOWEL SYNDROME

Rachel Buckle

Constipation: Paediatric and adult gastroenterologist

Maura Corsetti

UEG Week+ | Burnout in European Gastroenterology - A call to action

Martina Müller-Schilling

IBD

Matthew Ciorba

Nutrition: Getting the best out for the patient!

Christian Lodberg Hvas

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

IBD

Matthew Ciorba 1

Affiliations

1 Waschington University in Saint Louis, Waschington DC, United States of America

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Event

UEG Week Vienna 2024

Topics

Endoscopy Gut Microbiota IBD Oesophagus Stomach & H. Pylori

Session

Best of DDW

Citation

United European Gastroenterology Journal 2024; 12 (Supplement 8)

Published

2024

More Like This:

The role of endoscopy in diagnosis and monitoring of IBD: Present and future directions

Marietta Iacucci

THE MEDITERRANEAN DIET FOR IRRITABLE BOWEL SYNDROME

Rachel Buckle

Constipation: Paediatric and adult gastroenterologist

Maura Corsetti

UEG Week+ | Burnout in European Gastroenterology - A call to action

Martina Müller-Schilling

IBD

Matthew Ciorba

Nutrition: Getting the best out for the patient!

Christian Lodberg Hvas

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Nutrition: Getting the best out for the patient!

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

Nutrition: Getting the best out for the patient!

Christian Lodberg Hvas 1

Affiliations

1 Aarhus University Hospital, Aarhus N, Denmark

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Event

UEG Week Vienna 2024

Topics

Small Intestine & Nutrition Primary Care

Session

Crash course: Malabsorption

Citation

United European Gastroenterology Journal 2024; 12 (Supplement 8)

Published

2024

More Like This:

The role of endoscopy in diagnosis and monitoring of IBD: Present and future directions

Marietta Iacucci

THE MEDITERRANEAN DIET FOR IRRITABLE BOWEL SYNDROME

Rachel Buckle

Constipation: Paediatric and adult gastroenterologist

Maura Corsetti

UEG Week+ | Burnout in European Gastroenterology - A call to action

Martina Müller-Schilling

IBD

Matthew Ciorba

Nutrition: Getting the best out for the patient!

Christian Lodberg Hvas