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GORD Pathophysiology - Part 1

Daniel Sifrim, Kornilia Nikaki

Summary

AI Generated

An online course examines the multifactorial pathophysiology of gastro-oesophageal reflux disease by following the path of the refluxate through the stomach, antireflux barrier, clearance mechanisms, mucosa and symptom perception.

The pathophysiology of GORD is now understood to be multifactorial, evolving from earlier views that equated GORD with oesophagitis and hiatal hernia to include transient lower oesophageal sphincter relaxations, different phenotypes and microscopic features.
The course covers individual pathophysiological components including the stomach, antireflux barrier, refluxate, clearance mechanisms, mucosa and symptom perception.
A key learning objective is that patients with different GORD phenotypes may have different underlying pathophysiological mechanisms and may require different treatments even when presenting with similar symptoms.
The course is suitable for gastroenterologists in training, physicians and surgeons in other disciplines, nurses, biotechnicians and advanced-years medical students with an interest in gastroenterology.

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This summary was generated by an AI large language model based on the content transcript. It is for informational purposes only and should not be considered a substitute for clinical judgment. Always rely on your professional expertise and the full clinical context when making clinical decisions.

Overview

The diagnosis and treatment of gastro-oesophageal reflux disease (GORD) have been driven by our knowledge of its pathophysiology. From equating GORD with oesophagitis and hiatal hernia to identifying the role of transient lower oesophageal sphincter relaxations, different GORD phenotypes and microscopic features, the pathophysiology is now understood to be multifactorial.

This online course covers the different components that contribute to the pathophysiology of GORD by following the path of the refluxate. The role of the stomach, antireflux barrier, refluxate, clearance mechanisms, mucosa and symptom perception are each considered in turn.

Learning objectives

To understand that the pathophysiology of GORD is multifactorial
To become familiar with each of the individual pathophysiology abnormalities
To realize that patients with different GORD phenotypes may have different underlying pathophysiological mechanisms
To recognize that treatment of GORD should be designed to modify the specific pathophysiology
To appreciate that patients with GORD who have similar symptoms but different pathophysiology mechanisms may need different treatments

Target audience

This course is suitable for gastroenterologists in training, but is also appropriate for physicians and surgeons in other disciplines, as well as nurses, biotechnicians and advanced-years’ medical students who have an interest in gastroenterology.

Reviewed & updated February 2023

Event

GORD Pathophysiology Part 1

Topics

Neurogastroenterology & Motility Oesophagus

Accreditation status

accredited

Duration

1 hour

Published

2018

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UEG Online Course

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