Introduction
The optimal time for surgery after NAC for patients with SLM is still controversial. We plan to analyze whether the selection of different surgical timing will have different effects on the short-term clinical outcomes and long-term prognosis of patients.
Aims & Methods
We retrospectively collected all patients who met the inclusion and exclusion criteria from 2015 to 2020. Patients were grouped according to Time interval (TI) after NAC to surgery. The short-term and long-term clinical outcomes of the two groups were compared after propensity score matching. Univariate and multivariate analyzes were used to identify factors associated with patient prognosis.
Results
Among 152 enrolled patients, 98 were matched with comparable baseline (48 each group). In the matched cohort, postoperative ascites (8.3% vs. 22.9% , p = 0.049)
and bile leakage (4.2% vs. 16.7%, p = 0.045) occurred significantly more frequently in patients who underwent surgical resection 8~12 weeks after NAC than in patients who underwent surgery 4~8 weeks after NAC. Pleural effusion (31.3% vs. 12.5%, p = 0.026) occurred significantly more frequently in patients who underwent surgery 4~8 weeks after NAC. Although OS and DFS were not significantly different between the two groups, 13 factors were identified to be associated with patients' OS and DFS by multivariate analysis.
Conclusion
Although our study did not reveal a significant effect of timing of surgery after NAC on patient prognosis, there was a difference in the risk of certain postoperative complications between the two groups that warrants clinical attention. Randomized controlled trials are needed in the future to confirm these findings.
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