UEG's educational platform for gastroenterology education bringing recordings, courses, guidelines, and more together in one place.

UEG Week Berlin 2025 Recordings Gut Guide online

Rate for better recommendations!

Your feedback helps us show you more of what you like and less of what you dislike!

More of this!

We will show you more similar content.

Not for me!

We won't suggest this again.

Bookmark!

Save this content for later!

New to myUEG? Create an account! Log In with myUEG account

UEG Poster

Standard Poster

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

RELEVANCE OF RANDOM BIOPSY OF THE INCISURA ANGULARIS IN THE EVALUATION OF PREMALIGNANT GASTRIC CONDITIONS

Margarida Cristiano 1, Carlos Borges Chaves 1, Pedro Rocha 1, Diogo Feijó 1, Filipa Vidal Lima 1, Hugo Ribeiro 1, Rita Regatia 2, Nuno Peres Almeida 3, Pedro Narra Figueiredo 3

Affiliations

1 Unidade Local de Saúde de Coimbra, Coimbra, Portugal

2 Instituto Português de Oncologia de Coimbra Francisco Gentil, Coimbra, Portugal

3 Unidade Local de Saúde de Coimbra, Coimbra, Portugal|||Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal

Summary

AI Generated

A retrospective study of 192 patients found that adding an incisura angularis biopsy to standard gastric sampling changed OLGA or OLGIM staging in approximately 16% of cases but upgraded only three patients (1.6%) to high-risk stages.

The study evaluated the diagnostic value of adding a random incisura angularis biopsy to the RE.GA.IN protocol in 192 patients undergoing upper endoscopy with virtual chromoendoscopy.
High-risk OLGA stages were identified in 2.1% of patients and high-risk OLGIM stages in 7.8% of patients overall.
The additional incisura angularis biopsy altered OLGA scores in 16.1% and OLGIM scores in 15.6% of patients, but contributed to upgrading to high-risk stages in only three patients: two upgraded from OLGIM 0 to III and one from OLGA 0 to III.
The authors conclude that while the incisura angularis biopsy provides some additional diagnostic value, its impact on identifying high-risk patients and influencing surveillance intervals is limited.
This study is relevant to gastroenterologists determining optimal biopsy protocols for staging premalignant gastric conditions.

Download PDF

Was this helpful?

Thanks for your feedback.

This summary was generated by an AI large language model based on the content transcript. It is for informational purposes only and should not be considered a substitute for clinical judgment. Always rely on your professional expertise and the full clinical context when making clinical decisions.

Abstract

Introduction

The risk of developing gastric carcinoma is closely associated with the severity and extent of premalignant conditions, namely gastric atrophy and intestinal metaplasia. The most recent guidelines for screening and surveillance recommend collecting biopsies from at least two topographic sites (two from the antrum/incisura and two from the corpus, placed in separate and clearly labelled vials), considering incisura angularis biopsy as optional.

Aims & Methods

This study aims to assess the relevance of performing a random biopsy of the incisura angularis for the diagnosing and staging premalignant gastric conditions. We conducted a retrospective cohort study between November/2023 and January/2025, including patients undergoing screening upper endoscopy, endoscopy for dyspeptic symptoms or chronic gastritis monitoring. Biopsies were collected according to the RE.GA.IN protocol, with an additional biopsy from the incisura angularis placed in a third vial. Endoscopic and histological findings were collected and analyzed.

Results

A total of 192 patients underwent high-quality endoscopy, including virtual chromoendoscopy with Blue Light Imaging (57.3% female; mean age 59.6±15.2 years). Most procedures (56.3%) were performed without sedation, followed by anesthesia (23.4%) and conscious sedation (20.3%), with overall good (76.6%) and reasonable (16.7%) tolerance. High risk OLGA/OLGIM stages (III and IV) were identified in 2.1% and 7.8% of patients, respectively (OLGA: stage I-29.7%, II-5.7%, III - 2.1%; OLGIM: stage I - 18.8%, II - 18.8%, III - 7.3%, IV - 0.5%). The addition of a random incisura angularis biopsy altered the overall OLGA score in 16.1% of patients and the OLGIM score in 15.6%, but it contributed to an upgrade to high-risk stages in only three patients (1.6%). Specifically, in two patients, the OLGIM stage increased from 0 to III, and in one patient, the OLGA stage increased from 0 to III.

Conclusion

Our findings suggest that while the incisura angularis biopsy provides some additional diagnostic value, its impact on identifying high-risk patients and influencing the recommended endoscopic surveillance intervals is limited.

References

1. Rugge M, Genta RM, Malfertheiner P, et al. RE.GA.IN.: the Real-world Gastritis Initiative-updating the updates. Gut. 2024;73(3):407-441. Published 2024 Feb 23. doi:10.1136/gutjnl-2023-331164
2. Dinis-Ribeiro M, Libânio D, Uchima H, et al. Management of epithelial precancerous conditions and early neoplasia of the stomach (MAPS III): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG) and European Society of Pathology (ESP) Guideline update 2025. Endoscopy. 2025;57(5):504-554. doi:10.1055/a-2529-5025
3. Ferrari F, Ogata DC, Mello CAL. Role of incisura angularis biopsy in gastritis staging and risk assessment of gastric cancer. Arq Gastroenterol. 2023;60(4):478-489. doi:10.1590/S0004-2803.23042023-120

Conference

UEG Week Berlin 2025

Topics

Oesophagus

Submission format

Abstract

Session

Gastric preneoplastic conditions (Posters)

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

MASLD with Sven Francque - Part 1

Pradeep Mundre

EASL Clinical Practice Guidelines on vascular diseases of the liver

Project at a university hospital to reduce the CO2 footprint

Nils Andersen

Summary: Immunotherapy in digestive cancers - Where are we heading?

Tamara Matysiak-Budnik

Summary: UEG Journal Session

Sara Nikolić

Should we give probiotics a chance? For what?

Vanessa Stadlbauer-Köllner

UEG Podcast Episode

UEG Podcast

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

MASLD with Sven Francque - Part 1

Sven Francque, Pradeep Mundre

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Topics

Hepatobiliary

Published

2026

More Like This:

MASLD with Sven Francque - Part 1

Pradeep Mundre

EASL Clinical Practice Guidelines on vascular diseases of the liver

Project at a university hospital to reduce the CO2 footprint

Nils Andersen

Summary: Immunotherapy in digestive cancers - Where are we heading?

Tamara Matysiak-Budnik

Summary: UEG Journal Session

Sara Nikolić

Should we give probiotics a chance? For what?

Vanessa Stadlbauer-Köllner

UEG Standards and Guidelines

Clinical Practice Guideline

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

EASL Clinical Practice Guidelines on vascular diseases of the liver

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Guideline

Summary

Vascular diseases of the liver include portal vein thrombosis (with or without cirrhosis), portosinusoidal vascular disorder, Budd-Chiari syndrome, sinusoidal obstruction syndrome, non-obstructive sinusoidal dilatation and peliosis, splanchnic artery aneurysms, and hepatic arteriovenous fistulas. Except for portal vein thrombosis in cirrhosis, these are all rare conditions. Since the last Clinical Practice Guidelines were issued by the European Association for the Study of the Liver in 2016, much data has been published on the diagnosis and management – medical and interventional – of patients with vascular liver diseases. Based on a thorough review of the relevant literature, recommendations are provided to address key clinical dilemmas. The document emphasises personalised care, considering individual risk factors and clinical presentation. Multidisciplinary management involving hepatologists, haematologists, pathologists, interventional radiologists and surgeons is essential in this area. Our aim is to provide guidance on the management of patients with vascular liver diseases based on the best available evidence.

Publisher

European Association for the Study of the Liver

Guideline

Clinical Practice Guideline

Topics

Hepatobiliary

Citation

Journal of Hepatology; Volume 84, Issue 2, 399-456

Published

2025

More Like This:

MASLD with Sven Francque - Part 1

Pradeep Mundre

EASL Clinical Practice Guidelines on vascular diseases of the liver

Project at a university hospital to reduce the CO2 footprint

Nils Andersen

Summary: Immunotherapy in digestive cancers - Where are we heading?

Tamara Matysiak-Budnik

Summary: UEG Journal Session

Sara Nikolić

Should we give probiotics a chance? For what?

Vanessa Stadlbauer-Köllner

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Project at a university hospital to reduce the CO2 footprint

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

Project at a university hospital to reduce the CO2 footprint

Nils Andersen 1

Affiliations

1 UKE Hamburg-Eppendorf Abt. Endoskopie, Hamburg, Germany

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Event

UEG Week Berlin 2025

Topics

Nurses

Session

Green endoscopy: What makes sense?

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

MASLD with Sven Francque - Part 1

Pradeep Mundre

EASL Clinical Practice Guidelines on vascular diseases of the liver

Project at a university hospital to reduce the CO2 footprint

Nils Andersen

Summary: Immunotherapy in digestive cancers - Where are we heading?

Tamara Matysiak-Budnik

Summary: UEG Journal Session

Sara Nikolić

Should we give probiotics a chance? For what?

Vanessa Stadlbauer-Köllner

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Summary: Immunotherapy in digestive cancers - Where are we heading?

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

Summary: Immunotherapy in digestive cancers - Where are we heading?

Tamara Matysiak-Budnik 1

Affiliations

1 CHU de Nantes IMAD, Nantes, France

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Event

UEG Postgraduate Teaching Programme Berlin 2025

Topics

Digestive Oncology Immunology Mechanisms & Personalised Medicine

Session

Immunotherapy in digestive cancers: Where are we heading?

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

MASLD with Sven Francque - Part 1

Pradeep Mundre

EASL Clinical Practice Guidelines on vascular diseases of the liver

Project at a university hospital to reduce the CO2 footprint

Nils Andersen

Summary: Immunotherapy in digestive cancers - Where are we heading?

Tamara Matysiak-Budnik

Summary: UEG Journal Session

Sara Nikolić

Should we give probiotics a chance? For what?

Vanessa Stadlbauer-Köllner

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

Summary: UEG Journal Session

Sara Nikolić 1

Affiliations

1 University Medical Center Maribor, Maribor, Slovenia

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Event

UEG Week Berlin 2025

Topics

Nurses Pancreas Radiology & Imaging

Session

Hot topics in European gastroenterology

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

MASLD with Sven Francque - Part 1

Pradeep Mundre

EASL Clinical Practice Guidelines on vascular diseases of the liver

Project at a university hospital to reduce the CO2 footprint

Nils Andersen

Summary: Immunotherapy in digestive cancers - Where are we heading?

Tamara Matysiak-Budnik

Summary: UEG Journal Session

Sara Nikolić

Should we give probiotics a chance? For what?

Vanessa Stadlbauer-Köllner

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Should we give probiotics a chance? For what?

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

Should we give probiotics a chance? For what?

Vanessa Stadlbauer-Köllner 1

Affiliations

1 Center for Biomarker Research in Medicine (CBmed), Graz, Austria

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Event

UEG Week Berlin 2025

Topics

Gut Microbiota Primary Care

Session

The art of making clinical research precise: Can we unlock the microbiome?

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

MASLD with Sven Francque - Part 1

Pradeep Mundre

EASL Clinical Practice Guidelines on vascular diseases of the liver

Project at a university hospital to reduce the CO2 footprint

Nils Andersen

Summary: Immunotherapy in digestive cancers - Where are we heading?

Tamara Matysiak-Budnik

Summary: UEG Journal Session

Sara Nikolić

Should we give probiotics a chance? For what?

Vanessa Stadlbauer-Köllner

UEG's educational platform for gastroenterology education bringing recordings, courses, guidelines, and more together in one place.

Most popular content

Rate for better recommendations!