UEG's educational platform for gastroenterology education bringing recordings, courses, guidelines, and more together in one place.

UEG Week Berlin 2025 Recordings Gut Guide online

Rate for better recommendations!

Your feedback helps us show you more of what you like and less of what you dislike!

More of this!

We will show you more similar content.

Not for me!

We won't suggest this again.

Bookmark!

Save this content for later!

New to myUEG? Create an account! Log In with myUEG account

UEG Poster

Standard Poster

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

ARE RECTAL OR RECTOSIGMOID ENDOSCOPY SUFFICIENT TO ASSESS COMPLETE ENDOSCOPIC OR HISTOLOGICAL HEALING IN ULCERATIVE COLITIS: A CROSS-SECTIONAL STUDY

Clara Yzet 1, Capucine Moreau 1, Erica Meudjo 1, Camille Robert 1, Franck Brazier 1, Audrey Michaud 1, Mathurin Fumery 1

Affiliations

1 Amiens University Hospital, Amiens, France

Summary

AI Generated

A prospective study of 80 ulcerative colitis patients found rectosigmoidoscopy correlates almost perfectly with colonoscopy for assessing endoscopic and histological mucosal healing.

The correlation between rectosigmoidoscopy and colonoscopy was almost perfect for MAYO 0 endoscopic healing (kappa 0.949, p=0) with only 2 of 80 patients misclassified.
The correlation for histological healing between rectosigmoidoscopy and colonoscopy was almost perfect (kappa 0.877, p<0.001).
Rectoscopy alone also showed almost perfect correlation with colonoscopy for both MAYO 0 mucosal healing (kappa 0.826, p<0.001) and histological healing (kappa 0.8, p<0.001).
The authors conclude that rectosigmoidoscopy is sufficient to assess both endoscopic mucosal healing (MAYO 0 or 0-1) and histological healing in ulcerative colitis, with a false negative rate below 10%.

Download PDF

Was this helpful?

Thanks for your feedback.

This summary was generated by an AI large language model based on the content transcript. It is for informational purposes only and should not be considered a substitute for clinical judgment. Always rely on your professional expertise and the full clinical context when making clinical decisions.

Abstract

Introduction

At the time of treat to target, endoscopic healing is the goal to achieve in ulcerative colitis (UC). Colonoscopy (CO), rectosigmoidoscopy (RS) or rectoscopy can be performed to assess endoscopic healing. The objective of this study was to compare the performance of rectosigmoidoscopy with colonoscopy to predict endoscopic healing (EH) and histological healing.

Aims & Methods

This is a monocentric, prospective cohort of UC patients. All UC patients with a total colonoscopy were included between January 2021 and January 2023. Endoscopic and histological activity were measured using the MAYO endoscopic scores on each colonic segment and the Nancy Score, respectively. The correlation between RS or rectoscopy alone and CO in terms of endoscopic and histological mucosal healing was assessed using Cohen's kappa coefficient.
The study population was calculated according to the following assumptions: (1) absence of rectosigmoidoscopy lesions if absence of total colonoscopy lesions (0%), (2) 10% of lesions not seen in RS, (3) expected difference of 10% between CT and RS. 80 patients had to be included to demonstrate a significant difference in terms of EH between RS and CT with a bilateral alpha risk of 5% and a power of 81%.

Results

80 patients were included. 34 patients were MAYO 0 in RS and CO, 44 were not healed in RS and CO.. The correlation between the two exams was almost perfect with an index к of 0.949 (p=0) for MAYO 0 (2 patients misclassified), and к of 0.945 (p=0) for MAYO 0-1. The correlation between histological healing in RS and CO was almost perfect (к=0.877, p<0.001). Additionally, the correlation between rectoscopy and CT for the evaluation of mucosal healing MAYO 0 and histological healing was almost perfect (к=0.826 (p < 0.001) and к=0.8 (p < 0.001), respectively.

Conclusion

RS is sufficient in UC to assess both endoscopic mucosal healing (whether defined by a Mayo score of 0 or 1) and histological healing. With a false negative rate < 10%, rectoscopy could be a less invasive exam to assess healing in UC.

Conference

UEG Week Copenhagen 2023

Topics

IBD

Submission format

Abstract

Session

PP 05 IBD (Posters)

Citation

United European Gastroenterology Journal 2023; 11 (Supplement 8)

Published

2023

More Like This:

Episode 2: UEG Journal June spotlight

Maria Manuela Estevinho

THREE-ARM RANDOMIZED CONTROLLED TRIAL OF ACETIC ACID–INDIGO CARMINE MIXTURE (AIM) CHROMOCOLONOSCOPY FOR ENHANCED DETECTION OF PROXIMAL COLONIC SERRATED LESIONS

Motoyuki Otsuka

EFFECTIVENESS OF COLONOSCOPY ON EARLY ONSET COLORECTAL CANCER INCIDENCE AMONG PERSONS 40-49 YEARS

Hyunil Kim

Paediatric gastrostomy insertion

Christos Tzivinikos

HISTAMINE INTOLERANCE DUE TO DIAMINE OXIDASE DEFICIENCY MASQUERADING AS REFRACTORY IRRITABLE BOWEL SYNDROME: A DIAGNOSTIC CONSIDERATION

Iuliana Nenu (Chiorean Nenu)

Panel discussion: Hereditary GI cancer syndromes - Surveillance strategies

UEG Podcast Episode

Journal Podcast

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

Episode 2: UEG Journal June spotlight

Mohsan Subhani, Maria Manuela Estevinho

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Published

2025

More Like This:

Episode 2: UEG Journal June spotlight

Maria Manuela Estevinho

THREE-ARM RANDOMIZED CONTROLLED TRIAL OF ACETIC ACID–INDIGO CARMINE MIXTURE (AIM) CHROMOCOLONOSCOPY FOR ENHANCED DETECTION OF PROXIMAL COLONIC SERRATED LESIONS

Motoyuki Otsuka

EFFECTIVENESS OF COLONOSCOPY ON EARLY ONSET COLORECTAL CANCER INCIDENCE AMONG PERSONS 40-49 YEARS

Hyunil Kim

Paediatric gastrostomy insertion

Christos Tzivinikos

HISTAMINE INTOLERANCE DUE TO DIAMINE OXIDASE DEFICIENCY MASQUERADING AS REFRACTORY IRRITABLE BOWEL SYNDROME: A DIAGNOSTIC CONSIDERATION

Iuliana Nenu (Chiorean Nenu)

Panel discussion: Hereditary GI cancer syndromes - Surveillance strategies

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

THREE-ARM RANDOMIZED CONTROLLED TRIAL OF ACETIC ACID–INDIGO CARMINE MIXTURE (AIM) CHROMOCOLONOSCOPY FOR ENHANCED DETECTION OF PROXIMAL COLONIC SERRATED LESIONS

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

THREE-ARM RANDOMIZED CONTROLLED TRIAL OF ACETIC ACID–INDIGO CARMINE MIXTURE (AIM) CHROMOCOLONOSCOPY FOR ENHANCED DETECTION OF PROXIMAL COLONIC SERRATED LESIONS

Hideaki Kinugasa 1, Sakiko Hiraoka 1, Sayo Kobayashi 2, Minoru Matsubara 3, Teruya Nagahara 4, Reiji Higashi 5, Kensuke Takei 6, Masayasu Ohmori 7, Takashi Nakamura 8, Takao Tsuzuki 9, Ryosuke Hirai 1, Junki Toyosawa 1, Yuki Aoyama 1, Yasushi Yamasaki 1, Toshihiro Inokuchi 1, Masahiro Takahara 1, Takehiro Tanaka 1, Toshiharu Mitsuhashi 10, Motoyuki Otsuka 1

Affiliations

1 Okayama University Hospital, Okayama, Japan

2 Fukuyama City Hospital, Hiroshima, Japan

3 Sumitomo Besshi Hospital, Ehime, Japan

4 Mitoyo General Hospital, Kagawa, Japan

5 Ichinomiyanishi Hospital, Aichi, Japan

6 Tsuyama Chuo Hospital, Okayama, Japan

7 Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan

8 Takahashi Central Hospital, Okayama, Japan

9 Japanese Red Cross Society Himeji Hospital, Hyogo, Japan

10 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Introduction

Serrated lesions (SLs) in the proximal colon are increasingly recognized as important precursors to colorectal cancer (CRC), yet their detection remains challenging due to their flat morphology and subtle appearance. While chromoendoscopy using indigo carmine (IC) improves detection rates compared to white-light imaging (WLI), the utility of acetic acid-indigo carmine mixture (AIM)–based chromocolonoscopy remains unverified. This randomized controlled trial aimed to evaluate the efficacy of AIM compared to WLI and IC in detecting SLs in the proximal colon, with a focus on the impact of a second tandem examination.

Aims & Methods

In this multicenter, prospective, randomized controlled trial conducted at nine Japanese institutions, patients undergoing total colonoscopy were randomly assigned to three groups (WLI, IC, or AIM). All patients underwent a tandem examination of the proximal colon, defined as the region from the cecum to the hepatic flexure. The primary outcomes were the SL detection rate in the second observation (SDR2nd) and SL additional rate (SAR). Secondary outcomes included the detection and additional rates of other polys and factors contributing to SAR.

Results

A total of 1,319 patients were included in the per-protocol analysis. SDR2nd in the AIM group was significantly higher than that in the IC and WLI groups (14.0% vs. 7.9% vs. 2.7%, respectively). Similarly, ADR2nd was 24.7% in the AIM group, 22.2% in the IC group, and 10.5% in the WLI group. SAR was highest in the AIM group (69.3%), compared to 45.8% in IC and 22.4% in WLI. Multivariate logistic regression showed that AIM (OR 7.79, 95% CI: 3.76–17.08) and IC (OR 2.87, 95% CI: 1.37–6.28) were independently associated with improved SAR. GEE analysis indicated minimal interobserver variability. AIM also facilitated the detection of previously missed advanced SLs and sessile serrated polyposis syndrome (SPS), leading to changes in surveillance intervals.

Conclusion

AIM-based chromocolonoscopy significantly improves the detection of SLs in the proximal colon compared with IC and WLI. These findings support the incorporation of duplicate, contrast-enhanced examinations into routine colonoscopy practice and suggest AIM as a superior technique for detecting flat and mucus-covered SLs. Further studies are warranted to assess the long-term impact of improved SL detection on CRC incidence and mortality.

Event

UEG Week Berlin 2025

Topics

Colorectal Digestive Oncology Endoscopy

Submission format

Abstract

Session

Lower GI: Before resection comes a good characterisation

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

Episode 2: UEG Journal June spotlight

Maria Manuela Estevinho

THREE-ARM RANDOMIZED CONTROLLED TRIAL OF ACETIC ACID–INDIGO CARMINE MIXTURE (AIM) CHROMOCOLONOSCOPY FOR ENHANCED DETECTION OF PROXIMAL COLONIC SERRATED LESIONS

Motoyuki Otsuka

EFFECTIVENESS OF COLONOSCOPY ON EARLY ONSET COLORECTAL CANCER INCIDENCE AMONG PERSONS 40-49 YEARS

Hyunil Kim

Paediatric gastrostomy insertion

Christos Tzivinikos

HISTAMINE INTOLERANCE DUE TO DIAMINE OXIDASE DEFICIENCY MASQUERADING AS REFRACTORY IRRITABLE BOWEL SYNDROME: A DIAGNOSTIC CONSIDERATION

Iuliana Nenu (Chiorean Nenu)

Panel discussion: Hereditary GI cancer syndromes - Surveillance strategies

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

EFFECTIVENESS OF COLONOSCOPY ON EARLY ONSET COLORECTAL CANCER INCIDENCE AMONG PERSONS 40-49 YEARS

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

EFFECTIVENESS OF COLONOSCOPY ON EARLY ONSET COLORECTAL CANCER INCIDENCE AMONG PERSONS 40-49 YEARS

Hyun-Soo Kim 1, Su-Young Kim 1, Hyunil Kim 1

Affiliations

1 Wonju Severance Christian Hospital, Wonju, Korea, Republic of

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Introduction

Recently, some guidelines recommend conducting colorectal cancer (CRC) screening at ages younger than 50 years. However, there are few data on the preventive effect of colonoscopy at ages 40-49 years at the population level.

Aims & Methods

In this study, the risk of CRC according to the presence or absence of CSP in their 40s was evaluated in a retrospective cohort design using a nationwide database. Using the Korean National Health Insurance System data between 2004 and 2006, we constructed 1:5 colonoscopy cohort (CsC) and non-colonoscopy cohort (NCsC) at ages 40-49 years and followed through 2014. A total of 2,940,792 subjects were enrolled and CRC risk was evaluated after propensity score matching between CsC and NCsC based on age, sex, smoking, metabolic syndrome (MetS) and potentially relevant variables related CRC risk.

Results

Among 490,132 CsC subjects and 2,450,660 NCsC subjects at baseline periods in 40-49 ages, 689 (0.14%) and 9,440 (0.39%) cases of CRC were found during 10 years follow up period, respectively. According to age group, cumulative CRC incidences in early 40’s (40-44) were 0.10% in CsC and 0.25% in NCsC respectively. For late 40’s (45-49), those were 0.17% in CsC group and 0.49% in NCsC group, respectively. Compared with NCsC, the adjusted hazard ratios (aHRs) for CRC development in CsC group were 0.42 (men, 95% CI: 0.35-0.50) and 0.37 (women, 95% CI: 0.30-0.47) in early 40’s and 0.33 (men, 95% CI: 0.29-0.37) and 0.39 (women, 95% CI: 0.33-0.45) in late 40’s.

Conclusion

Overall, colonoscopy in their 40s significantly lowered the risk of colorectal cancer development by 58-67%. This cancer prevention effect of colonoscopy was different according to age and gender, and it was most effective in men in their late 40s, suggesting the rationales for optimization of age and gender to start colonoscopy.

Disclosure

Korea Health Technology R&D Project through the Korea Health Industry Development Institute, National Research Foundation of Korea grant and the National R&D Program for Cancer Control through the National Cancer Center funded by the Korea Ministry of Health & Welfare, Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education.

Event

UEG Week Vienna 2024

Topics

Colorectal Digestive Oncology Endoscopy

Submission format

Abstract

Session

Fit for CRC screening

Citation

United European Gastroenterology Journal 2024; 12 (Supplement 8)

Published

2024

More Like This:

Episode 2: UEG Journal June spotlight

Maria Manuela Estevinho

THREE-ARM RANDOMIZED CONTROLLED TRIAL OF ACETIC ACID–INDIGO CARMINE MIXTURE (AIM) CHROMOCOLONOSCOPY FOR ENHANCED DETECTION OF PROXIMAL COLONIC SERRATED LESIONS

Motoyuki Otsuka

EFFECTIVENESS OF COLONOSCOPY ON EARLY ONSET COLORECTAL CANCER INCIDENCE AMONG PERSONS 40-49 YEARS

Hyunil Kim

Paediatric gastrostomy insertion

Christos Tzivinikos

HISTAMINE INTOLERANCE DUE TO DIAMINE OXIDASE DEFICIENCY MASQUERADING AS REFRACTORY IRRITABLE BOWEL SYNDROME: A DIAGNOSTIC CONSIDERATION

Iuliana Nenu (Chiorean Nenu)

Panel discussion: Hereditary GI cancer syndromes - Surveillance strategies

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

Paediatric gastrostomy insertion

Christos Tzivinikos 1

Affiliations

1 Al Jalila Children's Specialty Hospital, DUBAI, United Arab Emirates

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Event

UEG Week Berlin 2025

Topics

Endoscopy Nurses Small Intestine & Nutrition Oesophagus Surgery

Session

Mistakes in…: Upper GI

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

Episode 2: UEG Journal June spotlight

Maria Manuela Estevinho

THREE-ARM RANDOMIZED CONTROLLED TRIAL OF ACETIC ACID–INDIGO CARMINE MIXTURE (AIM) CHROMOCOLONOSCOPY FOR ENHANCED DETECTION OF PROXIMAL COLONIC SERRATED LESIONS

Motoyuki Otsuka

EFFECTIVENESS OF COLONOSCOPY ON EARLY ONSET COLORECTAL CANCER INCIDENCE AMONG PERSONS 40-49 YEARS

Hyunil Kim

Paediatric gastrostomy insertion

Christos Tzivinikos

HISTAMINE INTOLERANCE DUE TO DIAMINE OXIDASE DEFICIENCY MASQUERADING AS REFRACTORY IRRITABLE BOWEL SYNDROME: A DIAGNOSTIC CONSIDERATION

Iuliana Nenu (Chiorean Nenu)

Panel discussion: Hereditary GI cancer syndromes - Surveillance strategies

UEG Poster

Audio / Video Poster

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

HISTAMINE INTOLERANCE DUE TO DIAMINE OXIDASE DEFICIENCY MASQUERADING AS REFRACTORY IRRITABLE BOWEL SYNDROME: A DIAGNOSTIC CONSIDERATION

Iuliana Nenu (Chiorean Nenu) 1

Affiliations

1 "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Cluj-Napoca, Romania

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Clinical Case Summary

A 54-year-old male with no significant past medical history presented with a five-year history of chronic gastrointestinal and systemic symptoms. He was initially diagnosed with irritable bowel syndrome (IBS) based on recurrent postprandial bloating, periumbilical abdominal discomfort, alternating diarrhea and constipation, and a persistent sensation of gastric fullness independent of food intake. Despite comprehensive management and a low-FODMAP diet, he reported minimal to no clinical improvement.
In addition to gastrointestinal complaints, the patient described recurrent headaches and chronic fatigue, both temporally associated with the consumption of histamine-rich foods such as red wine, aged cheeses, and processed meats. The neurological evaluation was unremarkable. Laboratory investigations were within normal limits, including complete blood count, inflammatory markers, liver and renal function tests, and celiac serologies. Gastroscopy and colonoscopy excluded structural, neoplastic, and inflammatory gastrointestinal pathology. However, serum diamine oxidase (DAO) activity was significantly decreased (2.8 U/mL; reference >10 U/mL), suggesting histamine intolerance secondary to DAO deficiency as the underlying etiology.
Therapeutic intervention included a strict low-histamine diet, oral DAO supplementation, and intermittent use of H1-antihistamines for symptomatic exacerbations. At a three-month follow-up, the patient reported substantial improvement in gastrointestinal and systemic symptoms, including normalizing bowel habits, resolution of headaches, and alleviating fatigue and bloating.
This case underscores the importance of considering histamine intolerance in patients with persistent IBS-like symptoms, particularly when conventional therapeutic strategies fail and symptom patterns suggest dietary histamine sensitivity. DAO activity testing may aid in diagnosis and guide effective, targeted therapy.

Disclosure

No Conflict of Interest.

Conference

UEG Week Berlin 2025

Topics

Small Intestine & Nutrition

Submission format

Clinical Case

Session

CLINICAL CASES (Posters)

Published

2025

More Like This:

Episode 2: UEG Journal June spotlight

Maria Manuela Estevinho

THREE-ARM RANDOMIZED CONTROLLED TRIAL OF ACETIC ACID–INDIGO CARMINE MIXTURE (AIM) CHROMOCOLONOSCOPY FOR ENHANCED DETECTION OF PROXIMAL COLONIC SERRATED LESIONS

Motoyuki Otsuka

EFFECTIVENESS OF COLONOSCOPY ON EARLY ONSET COLORECTAL CANCER INCIDENCE AMONG PERSONS 40-49 YEARS

Hyunil Kim

Paediatric gastrostomy insertion

Christos Tzivinikos

HISTAMINE INTOLERANCE DUE TO DIAMINE OXIDASE DEFICIENCY MASQUERADING AS REFRACTORY IRRITABLE BOWEL SYNDROME: A DIAGNOSTIC CONSIDERATION

Iuliana Nenu (Chiorean Nenu)

Panel discussion: Hereditary GI cancer syndromes - Surveillance strategies

UEG Presentation

Share via Email Share on Facebook Share on X Share on LinkedIn Share on Bluesky

Panel discussion: Hereditary GI cancer syndromes - Surveillance strategies

This content is part of Gutflix. Log in with your myUEG account, or create one free, to watch it.

Not sure what you can access? Learn more about account types.

Panel discussion: Hereditary GI cancer syndromes - Surveillance strategies

Summary

AI Generated

Summary is not available for this content yet.

Download PDF

Was this helpful?

Thanks for your feedback.

Abstract

Event

UEG Postgraduate Teaching Programme Berlin 2025

Topics

Colorectal Digestive Oncology Pancreas Stomach & H. Pylori

Session

Hereditary GI cancer syndromes: Surveillance strategies

Citation

United European Gastroenterology Journal 2025; 13 (Supplement 8)

Published

2025

More Like This:

Episode 2: UEG Journal June spotlight

Maria Manuela Estevinho

THREE-ARM RANDOMIZED CONTROLLED TRIAL OF ACETIC ACID–INDIGO CARMINE MIXTURE (AIM) CHROMOCOLONOSCOPY FOR ENHANCED DETECTION OF PROXIMAL COLONIC SERRATED LESIONS

Motoyuki Otsuka

EFFECTIVENESS OF COLONOSCOPY ON EARLY ONSET COLORECTAL CANCER INCIDENCE AMONG PERSONS 40-49 YEARS

Hyunil Kim

Paediatric gastrostomy insertion

Christos Tzivinikos

HISTAMINE INTOLERANCE DUE TO DIAMINE OXIDASE DEFICIENCY MASQUERADING AS REFRACTORY IRRITABLE BOWEL SYNDROME: A DIAGNOSTIC CONSIDERATION

Iuliana Nenu (Chiorean Nenu)

UEG's educational platform for gastroenterology education bringing recordings, courses, guidelines, and more together in one place.

Most popular content

Rate for better recommendations!