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Introduction

MASLD patients is increasing worldwide and the clinical outcomes of different phenotypes had shown varied especially the occurrence of of liver related events (LRE) or major cardiovascular events (MACE)(Eslam M, et al. Hepato Inter 2020, 14:889–919) In addition, the prognostic factors for LRE. or MACE. are not well studied.

Aims & Methods

Aims: We aimed to study the rate of LRE. or MACE and the predictors for LRE. Or MACE. in MASLD patients with liver biopsy proven.
Methods: In a single-tertiary-center prospective cohort, we collected data of MASLD patients with biopsy-proven who were followed up of at least 1 years at King Chulalongkorn Memorial Hospital during 2005-2022. The primary outcome was the presence of LRE. or MACE. which included cirrhotic complications: acute decompensations; EV/GV bleeding, ascites, hepatic encephalopathy or HCC or acute complications requiring liver transplantation or death. MACE was defined by the occurrence of stroke or acute coronary disease or myocardial infarction. Related baseline characteristics, LSM, FIB-4, and liver biopsy were collected.

Results

Among 286 MASLD patients, the MASLD patients with mean age of 50.1 +/- 14.5 years old (range 19-80 yr.) Male and female were 44% and 56 % respectively. MASLD patients were categorized into 3 groups which were type 2 diabetes mellitus (T2DM) in 119 (41.6%), overweight or obese group in 149 (52.1%), and lean MASLD (BMI<23) in 18 (6.3%). Their baseline characteristics were shown in Table 1.
The average BMI was 41.3 kg/m²(range 19.1-88.7). Other metabolic abnormalities were hypertension in 165 (57.7%), and dyslipidemia in 157 (54.9%). There were 6 cirrhotic cases (2.1%) at diagnosis. Presence of advanced liver fibrosis (TE>12KPA) was found in 15 cases (5.2%). After a mean follow-up of 9.5 years (range 1-19); there were 11 cases (3.8%) developed coronary artery disease and 3 cases (1%) developed stroke. LRE. were present in 7 cases (2.4%) which included acute decompensation (3 cases; 1%), HCC (3 cases; 1%), and death (1 cases; 0.3%). The overall complications of LRE. or MACE. were present in 16 cases (5.6%). By using multivariate analysis, the predictors of LRE. or MACE. were in presence of hypertriglyceridemia (aOR 1.01 (1.00-1.01); p =0.002) and older age (aOR 1.06 (1.01-1.11); p =0.023).

Variables	T2DM (n=119)	Overweight/Obese (n=149)	Lean(n=18)	P value
Age (years)	53.2±15.0	46.1±13.2	62.5±10.1	<0.001
BMI (kg/m²)	41.2±16.4	43.6±14.0	23.2±1.4	<0.001
Presence of DLP	84 (70.6%)	66 (44.3%)	7 (38.9%)	<0.001
AST (U/L)	45.1±30.0	38.7±33.5	75.7±57.1	<0.001
ALT (U/L)	64.7±42.6	61.6±47.7	94.8±50.9	0.01
Presence of advance fibrosis by TE>12 KPA (n=97)	9 (18.4%)	5 (13.2%)	1 (10.0%)	0.70
Presence of LRE.	9 (7.6%)	6 (4.0%)	1 (5.6%)	0.46
Presence of MACE.	7 (5.9%)	4 (2.7%)	1 (5.6%)	0.32

Conclusion

The overall complication of LRE. or MACE. was not uncommon (5.6% of this cohort with a mean follow-up of 9.5 years). Older age and hypertriglyceridemia were predictors of LRE. or MACE. occurrence.

References

Eslam M, et al. Hepato Inter 2020, 14:889–919.

PREDICTORS FOR MAJOR CARDIOVASCULAR EVENTS OR LIVER RELATED EVENTS IN LIVER BIOPSY PROVEN MASLD PATIENTS: A LONG-TERM FOLLOW-UP COHORT

Sombat Treeprasertsuk 1, Prooksa Ananchuensook 1, Kessarin Thanapirom 1, Chonlada Phathong 1

1 Chulalongkorn University, Patumwan, Thailand

Conference

UEG Week Vienna 2024

Topics

Hepatobiliary

Submission format

Abstract

Session

Epidemiology in MASLD (Posters)

Citation

United European Gastroenterology Journal 2024; 12 (Supplement 8)

Published

2024

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Introduction

Aims & Methods

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Conclusion

References

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